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Azarpira, Negar, Mardani, Ramin, Pourjafar, Mehrzad, Geramizadeh, Bita, Farokhi, Saeid. (1388). Primary Intracranial Malignant Nerve Sheath Tumor in the Cerebellopontine Angle in a Woman with Neurofibromatosis Type 2. سامانه مدیریت نشریات علمی, 34(2), 141-144.
Negar Azarpira; Ramin Mardani; Mehrzad Pourjafar; Bita Geramizadeh; Saeid Farokhi. "Primary Intracranial Malignant Nerve Sheath Tumor in the Cerebellopontine Angle in a Woman with Neurofibromatosis Type 2". سامانه مدیریت نشریات علمی, 34, 2, 1388, 141-144.
Azarpira, Negar, Mardani, Ramin, Pourjafar, Mehrzad, Geramizadeh, Bita, Farokhi, Saeid. (1388). 'Primary Intracranial Malignant Nerve Sheath Tumor in the Cerebellopontine Angle in a Woman with Neurofibromatosis Type 2', سامانه مدیریت نشریات علمی, 34(2), pp. 141-144.
Azarpira, Negar, Mardani, Ramin, Pourjafar, Mehrzad, Geramizadeh, Bita, Farokhi, Saeid. Primary Intracranial Malignant Nerve Sheath Tumor in the Cerebellopontine Angle in a Woman with Neurofibromatosis Type 2. سامانه مدیریت نشریات علمی, 1388; 34(2): 141-144.

Primary Intracranial Malignant Nerve Sheath Tumor in the Cerebellopontine Angle in a Woman with Neurofibromatosis Type 2

Iranian Journal of Medical Sciences
مقاله 10، دوره 34، شماره 2، شهریور 2009، صفحه 141-144    اصل مقاله (255.89 K)
نوع مقاله: Case Report(s)
نویسندگان
Negar Azarpira* ؛ Ramin Mardani؛ Mehrzad Pourjafar؛ Bita Geramizadeh؛ Saeid Farokhi
چکیده
Neurofibromatosis type 2 is an inherited disease. The main manifestation of the disease is the development of symmetric, non-malignant brain tumors in the region of the cranial nerve VIII usually as schwannoma. We report here a 20-year-old woman with primary intracranial malignant nerve sheath tumor located in the left cerebellopontine angle. Histologically, the tumor showed malignant spindle cells in fascicular pattern with focal S100 positivity on immunohistochemistry. A subtotal surgical resection was performed followed by adjuvant radiotherapy. This is the first case of primary intracranial malignant nerve sheath tumor associated with neurofibromatosis type 2 reported in the literature. The prognosis of this potentially aggressive neoplasm is poor.
کلیدواژه‌ها
Neurofibromatosis 2؛ malignant nerve sheath tumor؛ cerebellopontine angle
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