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Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 9، دوره 34، شماره 2، شهریور 2009، صفحه 137-140 اصل مقاله (150.5 K) | ||
| نوع مقاله: Brief Report(s) | ||
| نویسندگان | ||
| Mehran Karimi* ؛ Golam Reza Panahandeh Shahraki؛ Majid Yavarian؛ Abdolreza Afrasiabi؛ Javad Dehbozorgian؛ Mohammadreza Bordbar؛ Pier M. Mannucci | ||
| zand Ave, Nemazee Hospital | ||
| چکیده | ||
| Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of these mutations in a group of the population of southern Iran. In total, 198 healthy volunteers with the age range of 1-64 years were selected and screened for factor V Leiden and prothrombin mutations using polymerase chain reaction and restriction fragment length polymorphism techniques. The carrier frequencies for factor V Leiden and prothrombin mutation in the studied cohort were 4.1% and 3.07%, respectively.In the studied area, the allele frequency of factor V is higher than the prothrombin G20210A mutation (0.0204 v 0.0153). According to the data and Hardy-Weinberger equation, the total risk of thrombosis caused by homozygosity and heterozygosity of factor V Leiden, prothrombin G20210A mutation and compound heterozygosity of these mutations are about 1 in 500 individuals. | ||
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