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Motamedifar, Mohammad, Ghafari, Narjes, Talezadeh Shirazi, Pedram. (1389). The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture. سامانه مدیریت نشریات علمی, 35(4), 304-309.
Mohammad Motamedifar; Narjes Ghafari; Pedram Talezadeh Shirazi. "The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture". سامانه مدیریت نشریات علمی, 35, 4, 1389, 304-309.
Motamedifar, Mohammad, Ghafari, Narjes, Talezadeh Shirazi, Pedram. (1389). 'The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture', سامانه مدیریت نشریات علمی, 35(4), pp. 304-309.
Motamedifar, Mohammad, Ghafari, Narjes, Talezadeh Shirazi, Pedram. The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture. سامانه مدیریت نشریات علمی, 1389; 35(4): 304-309.

The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture

Iranian Journal of Medical Sciences
مقاله 6، دوره 35، شماره 4، اسفند 2010، صفحه 304-309    اصل مقاله (384.9 K)
نوع مقاله: Original Article(s)
نویسندگان
Mohammad Motamedifar* ؛ Narjes Ghafari؛ Pedram Talezadeh Shirazi
چکیده
Background: Cumin (Cuminum cyminum L. [family Apiaceae]) seed essential oil is reported to have antiseptic activity. Until now the antiviral properties of cumin seed extracts on viruses such as herpes simplex virus-1 (HSV-1) have not been studied. The objective of this study was to investigate the in vitro effects of aqueous, methanolic and hydroalcoholic extracts of cumin seed on HSV-1 growth in Vero cell line. Methods: Antiviral activity of various concentrations aqueous, hydroalcoholic and methanolic extracts of cumin seed in Vero cells were studied using plaque reduction assays. The 50% cytotoxic concentration (CC50), 50% inhibitory concentration (IC50), and therapeutic index of the effective extracts were calculated. Results: Methanolic extract of cumin seed showed a significant antiviral activity on HSV-1 in Vero cell line. Its CC50 for Vero cells, IC50 and the therapeutic index for HSV-1 were 0.45, 0.18 mg/mL and 2.5, respectively. Aqueous and hydroalcoholic extracts of cumin seeds showed no inhibitory effect on HSV-1. Conclusion: The methanolic extract of cumin seed produces anti-HSV-1 effect. Probable interference of phenolic compounds with fusion of Vero cell membrane and HSV-1 envelope might be the mechanism of such inhibitory effect. Further studies are required to ascertain its in vivo antiviral properties and potential toxicity.
کلیدواژه‌ها
Cumin seed؛ herpes simplex virus type-1؛ cell culture
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