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Thomas, Sithara, Senthilkumar, Gandhipuram Periyasamy, Sivaraman, Kuppuswamy, Bobby, Zachariah, Paneerselvam, Sankar, Harichandrakumar, Kotten Thazhath. (1393). Effect of S-Methyl-L-Cysteine on Oxidative Stress, Inflammation and Insulin Resistance in Male Wistar Rats Fed with High Fructose Diet. سامانه مدیریت نشریات علمی, 40(1), 45-50. doi: 10.30476/ijms.2015.39725
Sithara Thomas; Gandhipuram Periyasamy Senthilkumar; Kuppuswamy Sivaraman; Zachariah Bobby; Sankar Paneerselvam; Kotten Thazhath Harichandrakumar. "Effect of S-Methyl-L-Cysteine on Oxidative Stress, Inflammation and Insulin Resistance in Male Wistar Rats Fed with High Fructose Diet". سامانه مدیریت نشریات علمی, 40, 1, 1393, 45-50. doi: 10.30476/ijms.2015.39725
Thomas, Sithara, Senthilkumar, Gandhipuram Periyasamy, Sivaraman, Kuppuswamy, Bobby, Zachariah, Paneerselvam, Sankar, Harichandrakumar, Kotten Thazhath. (1393). 'Effect of S-Methyl-L-Cysteine on Oxidative Stress, Inflammation and Insulin Resistance in Male Wistar Rats Fed with High Fructose Diet', سامانه مدیریت نشریات علمی, 40(1), pp. 45-50. doi: 10.30476/ijms.2015.39725
Thomas, Sithara, Senthilkumar, Gandhipuram Periyasamy, Sivaraman, Kuppuswamy, Bobby, Zachariah, Paneerselvam, Sankar, Harichandrakumar, Kotten Thazhath. Effect of S-Methyl-L-Cysteine on Oxidative Stress, Inflammation and Insulin Resistance in Male Wistar Rats Fed with High Fructose Diet. سامانه مدیریت نشریات علمی, 1393; 40(1): 45-50. doi: 10.30476/ijms.2015.39725

Effect of S-Methyl-L-Cysteine on Oxidative Stress, Inflammation and Insulin Resistance in Male Wistar Rats Fed with High Fructose Diet

Iranian Journal of Medical Sciences
مقاله 7، دوره 40، شماره 1، فروردین 2015، صفحه 45-50    اصل مقاله (365.85 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2015.39725
نویسندگان
Sithara Thomas1؛ Gandhipuram Periyasamy Senthilkumar* 1؛ Kuppuswamy Sivaraman1؛ Zachariah Bobby1؛ Sankar Paneerselvam1؛ Kotten Thazhath Harichandrakumar2
1Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
2Department of Medical Biometrics and Informatics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
چکیده
Background: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. The purpose of the present study was to investigate the protective effect of SMC on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome.Methods: Male Wistar rats were divided into five groups (6 rats in each group), namely; control, control+S-methyl cysteine (SMC), high fructose diet (HFD), HFD+SMC and HFD+metformin. The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study. The fasting glucose, insulin, insulin resistance, and tumor necrosis factor alpha and erythrocyte enzymatic antioxidants were measured.Results: Increased levels of plasma glucose, insulin, malondialdehyde, tumor necrosis factor-alpha, and insulin resistance and decreased levels of glutathione, glutathione peroxidase, and catalase were found in rats on a high fructose diet. Oral administration of SMC (100 mg/kg bw/day/rat) for 60 days resulted in significant attenuation of plasma glucose, insulin, tumor necrosis factor–alpha, insulin resistance and improved antioxidant enzyme activities.Conclusion: Oral treatment of SMC is effective in improving insulin resistance while attenuating metabolic syndrome, inflammation, and oxidative stress in male rats fed with fructose rich diet.
کلیدواژه‌ها
Fructose؛ Insulin resistance؛ Inflammation؛ Oxidative stress
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