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Association between the Functional Polymorphism of Vascular Endothelial Growth Factor Gene and Breast Cancer: A Meta-Analysis | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 1، دوره 40، شماره 1، فروردین 2015، صفحه 2-12 اصل مقاله (1.78 M) | ||
| نوع مقاله: Review Article | ||
| نویسندگان | ||
| Juan Li؛ Yongjian Ju* | ||
| Department of Radiotherapy, The Second Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, Jiangsu Province, China | ||
| چکیده | ||
| The vascular endothelial growth factor (VEGF) gene single-nucleotide polymorphism involved in the regulation of the protein levels has been implicated in breast cancer. However, the published studies have produced contentious and controversial results. Herein, we performed a meta-analysis (from January to October 2013); to further evaluate the association between +936 C/T polymorphism and the risk of breast cancer. By searching the EMBASE, PubMed, and Web of Science databases, we identified a total of 12 case-control studies with 8,979 cancer patients and 9,180 healthy controls. The strength of the association was assessed using Odds Ratios (ORs) with 95% Confidence Intervals (CI). We found no evidence indicating that the allelic model or the genotype models of +936 C/T polymorphism were associated with the risk of breast cancer in total population (ORCC vs. TT=1.01, 95% CI=0.96-1.06, Ph=1.00; ORCC+CT vs. TT=1.00, 95% CI=0.96-1.05, Ph=1.00; ORCC vs. CT+TT=1.02, 95% CI=0.98-1.07, Ph=0.94; OR allele C vs. allele T=1.01, 95% CI=0.98-1.04, Ph=0.99; ORCT vs. TT=1.01, 95% CI=0.93-1.09, Ph=1.00). Such lack of association with breast cancer was also observed in subgroup analyses according to ethnicity as well as in the analysis by source of controls. In conclusion, this meta-analysis suggests that the functionally important +936 C/T polymorphism may not be associated with breast cancer risk. Larger well-designed studies with gene-to-gene and gene-to-environment interactions are clearly required to validate the results further. | ||
| کلیدواژهها | ||
| Vascular endothelial growth factor A؛ Breast neoplasms؛ Polymorphism؛ Risk | ||
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آمار تعداد مشاهده مقاله: 3,392 تعداد دریافت فایل اصل مقاله: 1,535 |
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