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Tanideh, Nader, Masoumi, Samira, Hosseinzadeh, Massood, Safarpour, Ali Reza, Erjaee, Hoda, Koohi-Hosseinabadi, Omid, Rahimikazerooni, Salar. (1393). Healing Effect of Pistacia Atlantica Fruit Oil Extract in Acetic Acid-Induced Colitis in Rats. سامانه مدیریت نشریات علمی, 39(6), 522-528.
Nader Tanideh; Samira Masoumi; Massood Hosseinzadeh; Ali Reza Safarpour; Hoda Erjaee; Omid Koohi-Hosseinabadi; Salar Rahimikazerooni. "Healing Effect of Pistacia Atlantica Fruit Oil Extract in Acetic Acid-Induced Colitis in Rats". سامانه مدیریت نشریات علمی, 39, 6, 1393, 522-528.
Tanideh, Nader, Masoumi, Samira, Hosseinzadeh, Massood, Safarpour, Ali Reza, Erjaee, Hoda, Koohi-Hosseinabadi, Omid, Rahimikazerooni, Salar. (1393). 'Healing Effect of Pistacia Atlantica Fruit Oil Extract in Acetic Acid-Induced Colitis in Rats', سامانه مدیریت نشریات علمی, 39(6), pp. 522-528.
Tanideh, Nader, Masoumi, Samira, Hosseinzadeh, Massood, Safarpour, Ali Reza, Erjaee, Hoda, Koohi-Hosseinabadi, Omid, Rahimikazerooni, Salar. Healing Effect of Pistacia Atlantica Fruit Oil Extract in Acetic Acid-Induced Colitis in Rats. سامانه مدیریت نشریات علمی, 1393; 39(6): 522-528.

Healing Effect of Pistacia Atlantica Fruit Oil Extract in Acetic Acid-Induced Colitis in Rats

Iranian Journal of Medical Sciences
مقاله 4، دوره 39، شماره 6، بهمن 2014، صفحه 522-528    اصل مقاله (1.1 M)
نوع مقاله: Original Article(s)
نویسندگان
Nader Tanideh1؛ Samira Masoumi2؛ Massood Hosseinzadeh3؛ Ali Reza Safarpour* 3؛ Hoda Erjaee4؛ Omid Koohi-Hosseinabadi5؛ Salar Rahimikazerooni3
1Shiraz Burn Research Center, Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
3Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
4Student Research Committee, Veterinary School, Shiraz University, Shiraz, Iran
5Center for Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Considering the anti-oxidant properties of Pistacia atlantica and lack of data regarding its efficacy in the treatment of ulcerative colitis, this study aims at investigating the effect of the Pistacia atlantica fruit extract in treating experimentally induced colitis in a rat model.Methods: Seventy male Sprague-Dawley rats (weighing 220±20 g) were used. All rats fasted 24 hours before the experimental procedure. The rats were randomly divided into 7 groups, each containing 10 induced colitis with 2ml acetic acid (3%). Group 1 (Asacol), group 2 (base gel) and group 7 (without treatment) were assigned as control groups. Group 3 (300 mg/ml) and group 4 (600 mg/ml) received Pistacia atlantica fruit orally. Group 5 (10% gel) and group 6 (20% gel) received Pistacia atlantica in the form of gel as enema. Macroscopic, histopathological examination and MDA measurement were carried out. Results: All groups revealed significant macroscopic healing in comparison with group 7 (P<0.001). Regarding microscopic findings in the treatment groups compared with group 7, the latter group differed significantly with groups 1, 2, 4 and 6 (P<0.001). There was a significant statistical difference in MDA scores of the seven treatment groups (F(5,54)=76.61, P<0.001). Post-hoc comparisons indicated that the mean±SD score of Asacol treated group (1.57±0.045) was not significantly different from groups 4 (1.62±0.024) and 6 (1.58±0.028).Conclusion: Our study showed that a high dose of Pistacia atlantica fruit oil extract, administered orally and rectally can improve colitis physiologically and pathologically in a rat model, and may be efficient for ulcerative colitis.
کلیدواژه‌ها
Enema؛ Colitis؛ Rat
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