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Assaei, Raheleh, Zal, Fatemeh, Mostafavi-Pour, Zohreh, Dabbaghmanesh, Mohammad Hossein, Geramizadeh, Bita, Ranjbar Omrani, Gholam Hossein, Pajouhi, Naser. (1393). Hepatoprotective Effect of Satureja Khuzestanica Essential Oil and Vitamin E in Experimental Hyperthyroid Rats: Evidence for Role of Antioxidant Effect. سامانه مدیریت نشریات علمی, 39(5), 459-466.
Raheleh Assaei; Fatemeh Zal; Zohreh Mostafavi-Pour; Mohammad Hossein Dabbaghmanesh; Bita Geramizadeh; Gholam Hossein Ranjbar Omrani; Naser Pajouhi. "Hepatoprotective Effect of Satureja Khuzestanica Essential Oil and Vitamin E in Experimental Hyperthyroid Rats: Evidence for Role of Antioxidant Effect". سامانه مدیریت نشریات علمی, 39, 5, 1393, 459-466.
Assaei, Raheleh, Zal, Fatemeh, Mostafavi-Pour, Zohreh, Dabbaghmanesh, Mohammad Hossein, Geramizadeh, Bita, Ranjbar Omrani, Gholam Hossein, Pajouhi, Naser. (1393). 'Hepatoprotective Effect of Satureja Khuzestanica Essential Oil and Vitamin E in Experimental Hyperthyroid Rats: Evidence for Role of Antioxidant Effect', سامانه مدیریت نشریات علمی, 39(5), pp. 459-466.
Assaei, Raheleh, Zal, Fatemeh, Mostafavi-Pour, Zohreh, Dabbaghmanesh, Mohammad Hossein, Geramizadeh, Bita, Ranjbar Omrani, Gholam Hossein, Pajouhi, Naser. Hepatoprotective Effect of Satureja Khuzestanica Essential Oil and Vitamin E in Experimental Hyperthyroid Rats: Evidence for Role of Antioxidant Effect. سامانه مدیریت نشریات علمی, 1393; 39(5): 459-466.

Hepatoprotective Effect of Satureja Khuzestanica Essential Oil and Vitamin E in Experimental Hyperthyroid Rats: Evidence for Role of Antioxidant Effect

Iranian Journal of Medical Sciences
مقاله 8، دوره 39، شماره 5، آذر 2014، صفحه 459-466    اصل مقاله (763.6 K)
نوع مقاله: Original Article(s)
نویسندگان
Raheleh Assaei1؛ Fatemeh Zal* 2؛ Zohreh Mostafavi-Pour3؛ Mohammad Hossein Dabbaghmanesh4؛ Bita Geramizadeh5؛ Gholam Hossein Ranjbar Omrani4؛ Naser Pajouhi6
1Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; and Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; and Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Recombinant Protein Lab, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; and Maternal-Fetal Medicine Research Center, Hafez Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
4Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. The hepatoprotective effect of Satureja Khuzestanica Essential Oil (SKEO), as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated. Methods: Adult male sprague dawley rats were divided into categories of; control (group C), hyperthyroid (group H), hyperthyroid with olive oil (group H+O), hyperthyroid with vitamin E (group H+E), hyperthyroid with SKEO (group H+S), combination of hyperthyroid with vitamin E and SKEO (group H+S+E). Hepatoprotective and antioxidant properties of SKEO with or without vitamin E in hyperthyroid rats were then investigated.Results: Serum Aspartate Transaminase (AST) and Alanine Transaminase (ALT) activities reduced significantly in H+O, H+E, H+S and H+S+E groups in comparison with hyperthyroid rats. Enzymes activities returned to normal in H+S+E group. Hepatic Malondialdehyde (MDA) was reduced in H+E, H+S and H+S+E groups in comparison with hyperthyroid rats. The most significant MDA reduction was in the H+S+E group. Glutathione Peroxidase (GPx) and Glutathione Reductase (GR) activities increased in H+E, H+S and H+S+E groups in comparison with group H. The largest increment in GPx and GR activities were in the H+S+E group. Glutathione level did not change in any group in comparison with the control group.Conclusion: Administration of SKEO has hepatoprotective effect in hyperthyroid rats and is more effective when used in combination with vitamin E.
کلیدواژه‌ها
Satureja؛ Oxidative stress؛ Rat
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