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Eftekhar, Ebrahim, Rasti, Mozhgan, Nahgibalhossaini, Fakhraddin, Sadeghi, Yasaman. (1393). The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients. سامانه مدیریت نشریات علمی, 39(3), 268-274.
Ebrahim Eftekhar; Mozhgan Rasti; Fakhraddin Nahgibalhossaini; Yasaman Sadeghi. "The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients". سامانه مدیریت نشریات علمی, 39, 3, 1393, 268-274.
Eftekhar, Ebrahim, Rasti, Mozhgan, Nahgibalhossaini, Fakhraddin, Sadeghi, Yasaman. (1393). 'The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients', سامانه مدیریت نشریات علمی, 39(3), pp. 268-274.
Eftekhar, Ebrahim, Rasti, Mozhgan, Nahgibalhossaini, Fakhraddin, Sadeghi, Yasaman. The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients. سامانه مدیریت نشریات علمی, 1393; 39(3): 268-274.

The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients

Iranian Journal of Medical Sciences
مقاله 5، دوره 39، شماره 3، مرداد 2014، صفحه 268-274    اصل مقاله (432.8 K)
نوع مقاله: Original Article(s)
نویسندگان
Ebrahim Eftekhar* 1؛ Mozhgan Rasti2؛ Fakhraddin Nahgibalhossaini2؛ Yasaman Sadeghi3
1Deparment of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;and Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Biochemistry, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2Deparment of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: DNA methyltransferase-3B (DNMT3B) is an important enzyme responsible for maintaining the DNA methylation pattern in eukaryotic cells. In this study we have investigated the correlation between the 46359C→T polymorphism in the DNMT3B gene and the risk of breast cancer incidence among sporadic breast cancer patients in Fars Province, Southern Iran.Methods: In this case-control study, 100 breast cancer patients and 138 healthy control subjects were genotyped for the DNMT3B gene by the polymerase chain reaction-restriction fragment length polymorphism method.Results: The genotype frequency in the case (CC 27%, CT 47%, TT 26%) group significantly (P=0.008) differed from the control (CC 19.56%, CT 67.3%, TT 13%) group. We observed a decreased association between the CT genotype and lymph node involvement in breast cancer patients. Our results have shown that in comparison to the homozygous CC genotype carriers the DNMT3B-CT genotype has a significantly lower risk for breast cancer (OR=0.515, 95% CI=0.267-0.994, P=0.048).Conclusion: Our case-control study showed that the CT genotype was significantly associated with decreased breast cancer risk. Consistent with these results, a significant decrease of CT genotype among lymph node positive breast cancer patients was observed. However, a larger study population with more clinical data is needed to confirm these results.
کلیدواژه‌ها
DNAmethyltransferase-3B؛ Polymorphism؛ Breast cance
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