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Hakimizadeh, Elham, Kazemi Arababadi, Mohammad, Shamsizadeh, Ali, Allahtavakoli, Mohammad, Rezvani, Mohammad Ebrahim, Roohbakhsh, Ali. (1393). Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats. سامانه مدیریت نشریات علمی, 39(3), 261-267.
Elham Hakimizadeh; Mohammad Kazemi Arababadi; Ali Shamsizadeh; Mohammad Allahtavakoli; Mohammad Ebrahim Rezvani; Ali Roohbakhsh. "Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats". سامانه مدیریت نشریات علمی, 39, 3, 1393, 261-267.
Hakimizadeh, Elham, Kazemi Arababadi, Mohammad, Shamsizadeh, Ali, Allahtavakoli, Mohammad, Rezvani, Mohammad Ebrahim, Roohbakhsh, Ali. (1393). 'Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats', سامانه مدیریت نشریات علمی, 39(3), pp. 261-267.
Hakimizadeh, Elham, Kazemi Arababadi, Mohammad, Shamsizadeh, Ali, Allahtavakoli, Mohammad, Rezvani, Mohammad Ebrahim, Roohbakhsh, Ali. Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats. سامانه مدیریت نشریات علمی, 1393; 39(3): 261-267.

Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats

Iranian Journal of Medical Sciences
مقاله 4، دوره 39، شماره 3، مرداد 2014، صفحه 261-267    اصل مقاله (452.69 K)
نوع مقاله: Original Article(s)
نویسندگان
Elham Hakimizadeh* 1؛ Mohammad Kazemi Arababadi2؛ Ali Shamsizadeh1؛ Mohammad Allahtavakoli1؛ Mohammad Ebrahim Rezvani3؛ Ali Roohbakhsh4
1Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Chronic use of opioids usually results in physical dependence. The underlying mechanisms for this dependence are still being evaluated. Transient receptor potential vanilloid type 1 (TRPV1) are important receptors of pain perception. Their role during opioid dependence has not been studied well. The aim of this study was to evaluate the effect of morphine-dependence on the expression of TRPV1 receptors in the amygdala and CA1 region of the hippocampus. Methods: This study used four groups of rats. Two groups of rats (morphine and morphine+naloxone) received morphine based on the following protocol: 10 mg/kg (twice daily, 3 days) followed by 20, 30, 40 and 50 mg/kg (twice daily), respectively, for 4 consecutive days. Another group received vehicle (1 ml/kg) instead of morphine given using the same schedule. The morphine+naloxone group of rats additionally received naloxone (5 mg/kg) at the end of the protocol. The control group rats received no injections or intervention. The amygdala and CA1 regions of the morphine, saline-treated and intact animals were isolated and prepared for real-time PCR analysis. Results: Administration of naloxone induced withdrawal signs in morphine-treated animals. The results showed a significant decrease in TRPV1 gene expression in the amygdala (P<0.05) but not the CA1 region of morphine dependent rats. Conclusion: TRPV1 receptors may be involved in morphine-induced dependence.
کلیدواژه‌ها
Vanilloid receptor subtype 1؛ CA1 region؛ Amygdala؛ Morphine؛ Rats
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