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Sahmeddini, Mohammad Ali, Janatmakan, Farahzad, Khosravi, Mohammad Bagher, Ghaffaripour, Sina, Eghbal, Mohammad Hossein, Shokrizadeh, Sakine. (1393). The Effect of Intraoperative Restricted Normal Saline during Orthotopic Liver Transplantation on Amount of Administered Sodium Bicarbonate. سامانه مدیریت نشریات علمی, 39(3), 247-253.
Mohammad Ali Sahmeddini; Farahzad Janatmakan; Mohammad Bagher Khosravi; Sina Ghaffaripour; Mohammad Hossein Eghbal; Sakine Shokrizadeh. "The Effect of Intraoperative Restricted Normal Saline during Orthotopic Liver Transplantation on Amount of Administered Sodium Bicarbonate". سامانه مدیریت نشریات علمی, 39, 3, 1393, 247-253.
Sahmeddini, Mohammad Ali, Janatmakan, Farahzad, Khosravi, Mohammad Bagher, Ghaffaripour, Sina, Eghbal, Mohammad Hossein, Shokrizadeh, Sakine. (1393). 'The Effect of Intraoperative Restricted Normal Saline during Orthotopic Liver Transplantation on Amount of Administered Sodium Bicarbonate', سامانه مدیریت نشریات علمی, 39(3), pp. 247-253.
Sahmeddini, Mohammad Ali, Janatmakan, Farahzad, Khosravi, Mohammad Bagher, Ghaffaripour, Sina, Eghbal, Mohammad Hossein, Shokrizadeh, Sakine. The Effect of Intraoperative Restricted Normal Saline during Orthotopic Liver Transplantation on Amount of Administered Sodium Bicarbonate. سامانه مدیریت نشریات علمی, 1393; 39(3): 247-253.

The Effect of Intraoperative Restricted Normal Saline during Orthotopic Liver Transplantation on Amount of Administered Sodium Bicarbonate

Iranian Journal of Medical Sciences
مقاله 2، دوره 39، شماره 3، مرداد 2014، صفحه 247-253    اصل مقاله (382.41 K)
نوع مقاله: Original Article(s)
نویسندگان
Mohammad Ali Sahmeddini* 1؛ Farahzad Janatmakan2؛ Mohammad Bagher Khosravi1؛ Sina Ghaffaripour1؛ Mohammad Hossein Eghbal1؛ Sakine Shokrizadeh1
1Shiraz Anesthesiology and Critical Care Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Anesthesiology and Critical Care, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Background: Severe metabolic acidosis occurs during orthotopic liver transplantation (OLT) particularly during the anhepatic phase. Although NaHCO3 is considered as the current standard therapy, there are numerous adverse effects. The aim of this study was to determine whether the restricted use of normal saline during anesthesia could reduce the need for NaHCO3.Methods: In this study we enrolled 75 patients with end-stage liver disease who underwent OLT from February 2010 until September 2010 at the Shiraz Organ Transplantation Center. Fluid management of two different transplant anesthetics were compared. The effect of restricted normal saline fluid was compared with non-restricted normal saline fluid on hemodynamic and acid-base parameters at three times during OLT: after the skin incision (T1), 15 min before reperfusion (T2), and 5 min after reperfusion (T3). Results: There were no significant differences in demographic characteristics of the donors and recipients (P>0.05). In the restricted normal saline group there was significantly lower central venous pressure (CVP) than in the non-restricted normal saline group (P=0.002). No significant differences were noted in the other hemodynamic parameters between the two groups (P>0.05). In the non-restricted normal saline group arterial blood pH (P=0.01) and HCO3 (P=0.0001) were significantly less than the restricted normal saline group. The NaHCO3 requirement before reperfusion was significantly more than with the restricted normal saline group (P=0.001).Conclusion: Restricted normal saline administration during OLT reduced the severity of metabolic acidosis and the need for NaHCO3 during the anhepatic phase.Trial Registration Number: IRCT2013110711662N5
کلیدواژه‌ها
Acidosis؛ Liver transplantation؛ Sodium bicarbonate؛ Crystalloid solution
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