LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,187
تعداد مقالات10,824
تعداد مشاهده مقاله72,829,770
تعداد دریافت فایل اصل مقاله12,909,659
Younessi, Parisa, Yoonessi, Ali. (1390). Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress. سامانه مدیریت نشریات علمی, 36(3), 154-166. doi: 10.30476/ijms.2011.39626
Parisa Younessi; Ali Yoonessi. "Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress". سامانه مدیریت نشریات علمی, 36, 3, 1390, 154-166. doi: 10.30476/ijms.2011.39626
Younessi, Parisa, Yoonessi, Ali. (1390). 'Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress', سامانه مدیریت نشریات علمی, 36(3), pp. 154-166. doi: 10.30476/ijms.2011.39626
Younessi, Parisa, Yoonessi, Ali. Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress. سامانه مدیریت نشریات علمی, 1390; 36(3): 154-166. doi: 10.30476/ijms.2011.39626

Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress

Iranian Journal of Medical Sciences
مقاله 1، دوره 36، شماره 3، آذر 2011، صفحه 154-166    اصل مقاله (341.53 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2011.39626
نویسندگان
Parisa Younessi* 1؛ Ali Yoonessi2
1Centre for Complementary Medicine Research, University of Western Syd-ney, Campbelltown Campus, Sydney, Australia; Faculty of Applied Science, University of Canberra, Canberra, Australia
2Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Science, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alz-heimer’s disease (AD). Activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progression of AD. It is also suggested that interaction between an advanced glycation end product (AGE) and its receptor (RAGE) results in glial activation as well as cy-tokine release and reactive oxygen species release. The use of antioxidants, receptor mediated compounds and reactive oxygen species scavenging enzyme produce an opportunity to in-tervene with AGE-RAGE signaling pathway, and thereby to slow down the progression of aging-related diseases.
کلیدواژه‌ها
Advanced glycation end producs؛ receptor for advanced glycation end products؛ oxidative stress؛ inflammation؛ signaling pathway
آمار
تعداد مشاهده مقاله: 4,300
تعداد دریافت فایل اصل مقاله: 1,715


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب