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Farimani Sanoee, Marzieh, Neghab, Nosrat, Rabiee, Soghra, Amiri, Iraj. (1390). Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome. سامانه مدیریت نشریات علمی, 36(2), 90-95.
Marzieh Farimani Sanoee; Nosrat Neghab; Soghra Rabiee; Iraj Amiri. "Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome". سامانه مدیریت نشریات علمی, 36, 2, 1390, 90-95.
Farimani Sanoee, Marzieh, Neghab, Nosrat, Rabiee, Soghra, Amiri, Iraj. (1390). 'Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome', سامانه مدیریت نشریات علمی, 36(2), pp. 90-95.
Farimani Sanoee, Marzieh, Neghab, Nosrat, Rabiee, Soghra, Amiri, Iraj. Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome. سامانه مدیریت نشریات علمی, 1390; 36(2): 90-95.

Metformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome

Iranian Journal of Medical Sciences
مقاله 4، دوره 36، شماره 2، شهریور 2011، صفحه 90-95    اصل مقاله (177.74 K)
نوع مقاله: Original Article(s)
نویسندگان
Marzieh Farimani Sanoee* 1؛ Nosrat Neghab1؛ Soghra Rabiee1؛ Iraj Amiri2
1Department of Obstetrics and Gynecology, Fatemieh Hospital, Hamedan, Iran
2The Center for Molecular Medicine Research, Hamedan University of Medical Sciences, Hamedan, Iran
چکیده
Background: It is well known that there is a close relationship between elevated androgen plasma levels and the ultrasound findings of stromal hypertrophy in polycystic ovary syndrome (PCOS). The objective of this study was to investigate the effects metformin on the hyperandrogenism and ovarian volume in PCOS.
Methods: The study is an unrandomized clinical trial with before–after design. Twenty eight patients with infertility (male or female factor) meeting the Rotterdam ESHRE/ASRM criteria for PCOS were studied during the 2008-2009. The anthropometric characteristics of the patients, mean bilateral ovarian volume, and morphology by trans vaginal sonography as well as the plasma levels of leutinizing hormone, follicle stimulating hormone, estradiol, testosterone, 17-α-hydroxyprogesterone, and dehydroepianderosterone sulfate were obtained before and after treatment with metformin (500 mg three times a day) for three months. Paired t, Pearson's Correlation Coefficient, or Partial Correlation test was used to analyze the findings.
Results: The patients had a mean age of 25.67 years. A significant reduction in mean ovarian volume (11.70±4.31 ml vs 8.27±3.71 ml P=0.001), body mass index (BMI, 28.11±4.55 kg/m2 vs 26.84±4.55 kg/m2 P=0.000) and serum androgen levels was seen after three months of treatment with metformin. There was positive correlations between the ovarian volume and serum testosterone level (r=0.589, P=0.001) or BMI (r=0.663, P=0.000).
Conclusion: Metformin therapy may lead to a reduction in ovarian volume. It is likely that the reduction of ovarian volume reflect a decrease in the mass of androgen producing tissues.
کلیدواژه‌ها
Polycystic ovarian syndrome؛ metformin؛ ovarian volume؛ hyperandrogenism
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