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Echocardiographic Evaluation of the Effects of a Single Bolus of Erythropoietin on Reducing Ischemia-Reperfusion Injuries during Coronary Artery Bypass Graft Surgery; A Randomized, Double-Blind, Placebo-Control Study | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 2، دوره 39، شماره 2، خرداد 2014، صفحه 94-101 اصل مقاله (421.75 K) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| Shervin Ziabakhsh-Tabary1؛ Rozita Jalalian2؛ Farzad Mokhtari-Esbuie* 3؛ Mohammad Reza Habibi4 | ||
| 1Department of Cardiac Surgery, Fatemeh Zahra Hospital, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 2Department of Cardiovascular, Fatemeh Zahra Hospital, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 3General Physician, Fatemeh Zahra Hospital, Mazandaran University of Medical Science, Sari, Iran | ||
| 4Department of Anesthesiology, Fatemeh Zahra Hospital, Mazandaran University of Medical Sciences, Sari, Iran | ||
| چکیده | ||
| Background: Erythropoietin (EPO) is known as a regulating hormone for the production of red blood cells, called erythropoiesis. Some studies have shown that EPO exerts some non-hematopoietic protective effects on ischemia-reperfusion injuries in myocytes. Using echocardiography, we evaluated the effect of EPO infusion on reducing ischemia-reperfusion injuries and improvement of the cardiac function shortly after coronary artery bypass graft surgery (CABG).Methods: Forty-three patients were recruited in this study and randomly divided into two groups: the EPO group, receiving standard medication and CABG surgery plus EPO (700 IU/kg), and the control group, receiving standard medication and CABG surgery plus normal saline (10 cc) as placebo. The cardiac function was assessed through echocardiography before as well as at 4 and 30 days after CABG.Results: Echocardiography indicated that the ejection fraction had no differences between the EPO and control groups at 4 days (47.05±6.29 vs. 45.90±4.97; P=0.334) and 30 days after surgery (47.27±28 vs. 46.62±5.7; P=0.69). There were no differences between the EPO and control groups in the wall motion score index at 4 (P=0.83) and 30 days after surgery (P=0.902). In the EPO group, there was a reduction in left ventricular end-systolic and end-diastolic diameters (LVESD and LVEDD, respectively), as compared to the control group.Conclusion: Our results indicated that perioperative exogenous EPO infusion could not improve the ventricular function and wall motion index in the immediate post-CABG weeks. Nevertheless, a reduction in LVEDD and LVESD at 4 days and 30 days after CABG in the EPO group, by comparison with the control group, suggested that EPO correlated with a reduction in the remodeling of myocytes and reperfusion injuries early after CABG.Trial Registration Number: 138809102799N1 | ||
| کلیدواژهها | ||
| Erythropoietin؛ Ischemia؛ Reperfusion injury؛ Coronary artery bypass graft | ||
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