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Ghaderi, Reza, Sehatbakhsh, Samineh, Bakhshaee, Mehdi, Sharifzadeh, Gholam Reza. (1392). Urinary Melatonin Levels and Skin Malignancy. سامانه مدیریت نشریات علمی, 39(1), 64-67.
Reza Ghaderi; Samineh Sehatbakhsh; Mehdi Bakhshaee; Gholam Reza Sharifzadeh. "Urinary Melatonin Levels and Skin Malignancy". سامانه مدیریت نشریات علمی, 39, 1, 1392, 64-67.
Ghaderi, Reza, Sehatbakhsh, Samineh, Bakhshaee, Mehdi, Sharifzadeh, Gholam Reza. (1392). 'Urinary Melatonin Levels and Skin Malignancy', سامانه مدیریت نشریات علمی, 39(1), pp. 64-67.
Ghaderi, Reza, Sehatbakhsh, Samineh, Bakhshaee, Mehdi, Sharifzadeh, Gholam Reza. Urinary Melatonin Levels and Skin Malignancy. سامانه مدیریت نشریات علمی, 1392; 39(1): 64-67.

Urinary Melatonin Levels and Skin Malignancy

Iranian Journal of Medical Sciences
مقاله 9، دوره 39، شماره 1، فروردین 2014، صفحه 64-67    اصل مقاله (209.72 K)
نوع مقاله: Brief Report(s)
نویسندگان
Reza Ghaderi* 1؛ Samineh Sehatbakhsh2؛ Mehdi Bakhshaee2؛ Gholam Reza Sharifzadeh3
1Department of Dermatology, Birjand University of Medical Sciences, Birjand, Iran
2The Sinus and Endoscopic Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Mashhad, Iran
3Department of Epidemiology, Birjand University of Medical Sciences, Birjand, Iran
چکیده
Melatonin inhibits tumor genesis in a variety of in vivo and in vitro experimental models of neoplasia. In industrialized societies, light at night, by suppressing melatonin production, poses a new risk for the development of a variety of cancers such as breast cancer. This effect on skin has been previously studied only in animals and not in humans. Our goal was to examine the relationship between 24-hour 6-sulphatoxymelatonin levels and skin cancer in a case-control study of 70 patients with skin cancer and 70 healthy individuals. The level of 6-sulfatoxymelatonin was measured in 24-hour urine by the ELISA method. In the case group, 55 (78%) patients had basal cell carcinoma and 15 (22%) had squamous cell carcinoma. The mean level of 24-hour urine 6-sulfatoxymelatonin was significantly higher in the control group (P<0.001). Also, sleep duration had a significant difference between the two groups (P=0.001). It seems that a low level of 24-hour urinary 6-sulfatoxymelatonin renders human beings prone to skin cancer. This association, however, requires further investigation.
کلیدواژه‌ها
Melatonin؛ Skin neoplasm؛ Basal cell carcinoma؛ Squamous cell carcinoma
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