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Zekavat, Omid Reza, Makarem, Ali Reza, Haghpanah, Sezaneh, Karamizadeh, Zohreh, Javad, Parvin, Karimi, Mehran. (1392). Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea. سامانه مدیریت نشریات علمی, 39(1), 60-63.
Omid Reza Zekavat; Ali Reza Makarem; Sezaneh Haghpanah; Zohreh Karamizadeh; Parvin Javad; Mehran Karimi. "Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea". سامانه مدیریت نشریات علمی, 39, 1, 1392, 60-63.
Zekavat, Omid Reza, Makarem, Ali Reza, Haghpanah, Sezaneh, Karamizadeh, Zohreh, Javad, Parvin, Karimi, Mehran. (1392). 'Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea', سامانه مدیریت نشریات علمی, 39(1), pp. 60-63.
Zekavat, Omid Reza, Makarem, Ali Reza, Haghpanah, Sezaneh, Karamizadeh, Zohreh, Javad, Parvin, Karimi, Mehran. Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea. سامانه مدیریت نشریات علمی, 1392; 39(1): 60-63.

Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea

Iranian Journal of Medical Sciences
مقاله 8، دوره 39، شماره 1، فروردین 2014، صفحه 60-63    اصل مقاله (210.94 K)
نوع مقاله: Brief Report(s)
نویسندگان
Omid Reza Zekavat* 1؛ Ali Reza Makarem2؛ Sezaneh Haghpanah1؛ Zohreh Karamizadeh3؛ Parvin Javad1؛ Mehran Karimi1
1Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran
3Department of Pediatric Endocrinology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum levels of thyroid stimulating hormone (TSH) and T4 were measured. The mean age of the participants was 22.7±5.1 years (age range=12-41 years). Serum ferritin level had no significant correlation with HU consumption (P>0.05). Overall, we detected 10 (9.4%) patients with hypothyroidism. We found that the use of HU at a dose of 8-15 mg/kg/day has no significant association with thyroid function in β-TI patients. However, due to the small sample size in our study, documentation of this finding needs further studies with higher numbers of patients.
کلیدواژه‌ها
Thalassemia intermedia؛ Hydroxyurea؛ Thyroid function
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