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Tolide-ie, Hamidreza, Tabatabaee, Hamid Reza, Kamali-Sarvestani, Eskandar. (1392). Association between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 39(1), 2-10.
Hamidreza Tolide-ie; Hamid Reza Tabatabaee; Eskandar Kamali-Sarvestani. "Association between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis". سامانه مدیریت نشریات علمی, 39, 1, 1392, 2-10.
Tolide-ie, Hamidreza, Tabatabaee, Hamid Reza, Kamali-Sarvestani, Eskandar. (1392). 'Association between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis', سامانه مدیریت نشریات علمی, 39(1), pp. 2-10.
Tolide-ie, Hamidreza, Tabatabaee, Hamid Reza, Kamali-Sarvestani, Eskandar. Association between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 1392; 39(1): 2-10.

Association between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis

Iranian Journal of Medical Sciences
مقاله 1، دوره 39، شماره 1، فروردین 2014، صفحه 2-10    اصل مقاله (406.04 K)
نوع مقاله: Review Article
نویسندگان
Hamidreza Tolide-ie* 1؛ Hamid Reza Tabatabaee2؛ Eskandar Kamali-Sarvestani3
1Faculty of Health, Gonabad University of Medical Sciences, Gonabad, Iran
2Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
3Shiraz Autoimmune Diseases Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Multiple sclerosis (MS) is a complex polygenic disease in which gene-environment interactions are important. A number of studies have investigated the association between tumor necrosis factor-α (TNF-α) -308 G/A polymorphism (substitution G→A, designated as TNF1 and TNF2) and MS susceptibility in different populations, but the results of individual studies have been inconsistent. Therefore, performing a systematic review and meta-analysis of the published studies is desirable. We sought to quantitatively summarize the association between TNF-α-308 G/A polymorphism and MS. The Medline and Scopus databases were searched to identify potentially relevant case-control studies published in English journals up to January 2010. A meta-analysis of these studies was performed. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under fixed and random effects models. Twenty-one eligible studies, comprising 2880 patients with MS and 3579 controls, were included in the meta-analysis. The overall pooled ORs (95%CI) for TNF2 versus TNF1 and TNF2 carriers (2/2+2/1) versus non-carriers (1/1) were 1.02 (0.86-1.21) and 0.99 (0.8-1.24), respectively. In the European populations, the pooled ORs (95%CI) for TNF 2/1 versus 1/1 were 0.85 (0.73-0.98), which was statistically significant. However, the other results did not support this finding. The pooled ORs (95%CI) for TNF 2/1 versus 1/1 and TNF 2/2 versus 2/1 were not statistically significant in the overall population. In addition, the pooled ORs for TNF2/2 versus TNF2/1+1/1 and TNF2/2 versus TNF1/1 were not statistically significant. Our meta-analysis does not support the role of TNF-α -308 G/A polymorphism in developing MS.
کلیدواژه‌ها
Multiple sclerosis؛ Systematic review؛ Meta-analysis؛ Polygenic؛ Gene
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