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Protective Effect of Vitamins E and C on Endosulfan-Induced Reproductive Toxicityin Male Rats | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 4، دوره 37، شماره 3، آذر 2012، صفحه 173-180 اصل مقاله (417.64 K) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/ijms.2012.39566 | ||
| نویسندگان | ||
| Mohammad Ali Takhshid* 1؛ Ali Reza Tavasuli2؛ Yazdan Heidary3؛ Mojtaba Keshavarz3؛ Hussain Kargar3 | ||
| 1Department of Anesthesiology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Department of Anesthesiology, Faculty of ParaMedicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2Department of Anesthesiology, Faculty of ParaMedicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 3Medical Library and Information Sciences, Faculty of ParaMedicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| چکیده | ||
| Background: The role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. This study was performed to evaluate the possible protective effect of vitamins E and C, against endosulfan-induced reproductive toxicity in rats. Methods: Fifty adult male Sprague–Dawley rats were randomly divided into five groups (n=10 each). The groups included a control receiving vehicle, a group treated with endosulfan (10 mg/kg/day) alone, and three endosulfan-treated group receiving vitamin C (20 mg/kg/day), vitamin E (200 mg/kg/day), or vitamine C+vitamin E at the same doses. After 10 days of treatment, sperm parameters, plasma lactate dehydrogenase (LDH), plasma testosterone and malondialdehyde (MDA) levels in the testis were determined. Results: Oral administration of endosulfan caused a reduction in the sperm motility, viability, daily sperm production (DSP) and increased the number of sperm with abnormal chromatin condensation. Endosulfan administration increased testis MDA and plasma LDH. Supplementation of vitamin C and vitamin E to endosulfan-treated rats reduced the toxic effect of endosulfan on sperm parameters and lipid peroxidation in the testis. Vitamin E was more protective than vitamin C in reducing the adverse effects of the endosulfan. Conclusion: The findings data suggest that administration of vitamins C and E ameliorated the endosulfan-induced oxidative stress and sperm toxicity in rat. The effect of vitamin E in preventing endosulfan-induced sperm toxicity was superior to that of vitamin C. | ||
| کلیدواژه‌ها | ||
| Endosulfan؛ spermatogenesis؛ oxidative stress؛ vitamin E؛ vitamin C | ||
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