پیوندهای مفید
آمار
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| تعداد شمارهها | 1,092 |
| تعداد مقالات | 10,022 |
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| تعداد دریافت فایل اصل مقاله | 7,452,248 |
Comparison of Cytotoxic Activity of Bile on HepG2 and CCRF-CEM Cell Lines: An in Vitro Study | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 7، دوره 37، شماره 4، اسفند 2012، صفحه 266-270 اصل مقاله (582.53 K) | ||
| نوع مقاله: Brief Report(s) | ||
| نویسندگان | ||
| Negar Azarpira* ؛ Fatemeh Rastegar؛ Maryam Amiri؛ Elaheh Esfandiari؛ Bita Geramizadeh | ||
| Organ Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| The aim of this study was to examine the effect of crude bile on the human HepG2 and CCRF-CEM cell lines. Cells were exposed to different dilutions of bile. Antiproliferative effects were determined by the cytotoxic MTT assay. Cells undergoing apoptosis were identified by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Bile administration resulted in dose-dependent cytotoxicity in both HepG2 and CCRF-CEM cell lines. Incubated cells exhibited morphologic features of apoptosis. Bile has significant cytotoxic activity in HepG2 and CCRF-CEM cancer cells via induction of apoptosis. The mechanism of apoptosis needs to be further evaluated. It may have clinical utility in the treatment of cancer after in vivo confirmation of activity. | ||
| کلیدواژهها | ||
| Bile؛ Neoplasms؛ Cytotoxicity | ||
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آمار تعداد مشاهده مقاله: 1,969 تعداد دریافت فایل اصل مقاله: 780 |
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