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Shokrgozar, Mohammad Ali, Habibi Roudkenar, Mehryar, Bahmani, Parisa, Halabian, Raheleh, Mohammadi Roushandeh, Amaneh, Jahanian Najafabadi, Ali. (1390). HESA-A Exerts Its Cytoprotective Effects through Scavenging of Free Radicals: An in Vitro Study. سامانه مدیریت نشریات علمی, 37(1), 47-53.
Mohammad Ali Shokrgozar; Mehryar Habibi Roudkenar; Parisa Bahmani; Raheleh Halabian; Amaneh Mohammadi Roushandeh; Ali Jahanian Najafabadi. "HESA-A Exerts Its Cytoprotective Effects through Scavenging of Free Radicals: An in Vitro Study". سامانه مدیریت نشریات علمی, 37, 1, 1390, 47-53.
Shokrgozar, Mohammad Ali, Habibi Roudkenar, Mehryar, Bahmani, Parisa, Halabian, Raheleh, Mohammadi Roushandeh, Amaneh, Jahanian Najafabadi, Ali. (1390). 'HESA-A Exerts Its Cytoprotective Effects through Scavenging of Free Radicals: An in Vitro Study', سامانه مدیریت نشریات علمی, 37(1), pp. 47-53.
Shokrgozar, Mohammad Ali, Habibi Roudkenar, Mehryar, Bahmani, Parisa, Halabian, Raheleh, Mohammadi Roushandeh, Amaneh, Jahanian Najafabadi, Ali. HESA-A Exerts Its Cytoprotective Effects through Scavenging of Free Radicals: An in Vitro Study. سامانه مدیریت نشریات علمی, 1390; 37(1): 47-53.

HESA-A Exerts Its Cytoprotective Effects through Scavenging of Free Radicals: An in Vitro Study

Iranian Journal of Medical Sciences
مقاله 8، دوره 37، شماره 1، خرداد 2012، صفحه 47-53    اصل مقاله (357.82 K)
نوع مقاله: Original Article(s)
نویسندگان
Mohammad Ali Shokrgozar* 1؛ Mehryar Habibi Roudkenar2؛ Parisa Bahmani2؛ Raheleh Halabian2؛ Amaneh Mohammadi Roushandeh3؛ Ali Jahanian Najafabadi4
1National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
2Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
3Department of Anatomy, Faculty of Medicine, Medical University of Hamadan, Hamadan, Iran
4Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran
چکیده
Background: Natural medicines have been recently considered more reasonable for human use most notably due to their safety and tolerance. HESA-A is a marine-originated herbal medicine with a variety of healing effects. However, its exact biological mechanism is not clear. The pre-sent study aimed at the evaluation of the HESA-A antioxidant effect.
Methods: Chinese hamster ovary (CHO) and human embryonic kidney (HEK293T) cells were treated with different concentrations of HESA-A and H2O2 followed by cell proliferation assays. The antioxidant effect of the HESA-A preparations was evaluated by an antioxidant assay kit.
Results: The viability of CHO and HEK293T cells were about 89% following their incubation with 100 and 200 ng/ml HESA-A, respectively for 1.5 hrs. However, when the cells were incubated with concentrations of 300 ng/ml or more, the cell viability significantly decreased to 48% compare to the control cells. The cytotoxic effects of H2O2 were observed after 2 hrs of incubation of the HEK293T or CHO cells with 10 mM or 16 mM H2O2, respectively, while in the presence of HESA-A the cytotoxicity was significantly decreased. Antioxidant assay revealed that HESA-A scavenges free radicals.
Conclusion: The findings indicate that HESA-A had cytoprotective effects in vitro, and that such an effect might be due to antioxidant properties.
کلیدواژه‌ها
HESA-A؛ reactive oxygen species؛ hydrogen peroxide
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