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Hj Suhaimi, Farihah, Mohd Ramli, Elvy Suhana, Soelaiman, Ima Nirwana, Othman, Faizah, Ahmad, Fairus, Nazrun Shuib, Ahmad, Mohamed, Norazlina, Muhammad, Norliza. (1390). The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids. سامانه مدیریت نشریات علمی, 37(1), 39-46.
Farihah Hj Suhaimi; Elvy Suhana Mohd Ramli; Ima Nirwana Soelaiman; Faizah Othman; Fairus Ahmad; Ahmad Nazrun Shuib; Norazlina Mohamed; Norliza Muhammad. "The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids". سامانه مدیریت نشریات علمی, 37, 1, 1390, 39-46.
Hj Suhaimi, Farihah, Mohd Ramli, Elvy Suhana, Soelaiman, Ima Nirwana, Othman, Faizah, Ahmad, Fairus, Nazrun Shuib, Ahmad, Mohamed, Norazlina, Muhammad, Norliza. (1390). 'The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids', سامانه مدیریت نشریات علمی, 37(1), pp. 39-46.
Hj Suhaimi, Farihah, Mohd Ramli, Elvy Suhana, Soelaiman, Ima Nirwana, Othman, Faizah, Ahmad, Fairus, Nazrun Shuib, Ahmad, Mohamed, Norazlina, Muhammad, Norliza. The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids. سامانه مدیریت نشریات علمی, 1390; 37(1): 39-46.

The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids

Iranian Journal of Medical Sciences
مقاله 7، دوره 37، شماره 1، خرداد 2012، صفحه 39-46    اصل مقاله (2.33 M)
نوع مقاله: Original Article(s)
نویسندگان
Farihah Hj Suhaimi* 1؛ Elvy Suhana Mohd Ramli1؛ Ima Nirwana Soelaiman2؛ Faizah Othman1؛ Fairus Ahmad1؛ Ahmad Nazrun Shuib2؛ Norazlina Mohamed2؛ Norliza Muhammad2
1Department of Anatomy, Universiti Kebangsaan Malaysia, Kuala Lumpur, WP, Malaysia
2Department of Pharmacology, Universiti Kebangsaan Malaysia, Kuala Lumpur, WP, Malaysia
چکیده
Background: Long-term glucocorticoid therapy causes secondary osteoporosis leading to pathological fractures. Glucocorticoid action in bone is dependant upon the activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1). Piper sarmentosum
is a local herb that possesses the ability to inhibit 11-βHSD1 enzyme activity. We aimed to determine the effects of Piper sarmentosum water extract on 11-βHSD1 expressions and activity in the bones of glucocorti-coid-treated adrenalectomized rats.
Methods: Forty male Sprague–Dawley rats (200-250 g) were used. Twenty-four animals were adrenalectomized and received intramuscular injection of dexamethasone (120 μg/kg/day). They were simultaneously administered with either Piper sarmentosum water extract (125 mg/kg/day), GCA (120 mg/kg/day) or distilled water as vehicle by oral gavage for two months. Eight animals were sham-operated and given vehicle daily, i.e. intramuscular olive oil and oral distilled water.
Results: Following two months treatment, dexamethasone-treated adrenalectomized rats had significantly lower 11β-HSD1 dehydrogenase activity and higher 11β-HSD1 expression in the femoral bones compared to the sham-operated and baseline group. The rats supplemented with Piper sarmentosum water extract had significantly higher 11β-HSD1 dehydrogenase activity and lower 11β-HSD1 expression in the bones.
Conclusion: The results showed that Piper sarmentosum water extract had the ability to prevent glucocorcoticoid excess in the bones of glucocorticoid-treated adrenalectomized rats through the local modulation of 11β-HSD1 expression and activity, and may be used as prophylaxis for osteoporosis in patients on long-term glucocorticoid treatment.
کلیدواژه‌ها
Piper sarmentosum؛ 11β-hydroxysteroid dehydrogenase type 1؛ dexamethasone؛ glucocorticoids؛ osteoporosis
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