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Yousefinejad, Abbas, Mazloom, Zohreh, Dabbaghmanesh, Mohammad Hossein. (1391). Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial. سامانه مدیریت نشریات علمی, 38(1), 38-43. doi: 10.30476/ijms.2013.39511
Abbas Yousefinejad; Zohreh Mazloom; Mohammad Hossein Dabbaghmanesh. "Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial". سامانه مدیریت نشریات علمی, 38, 1, 1391, 38-43. doi: 10.30476/ijms.2013.39511
Yousefinejad, Abbas, Mazloom, Zohreh, Dabbaghmanesh, Mohammad Hossein. (1391). 'Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial', سامانه مدیریت نشریات علمی, 38(1), pp. 38-43. doi: 10.30476/ijms.2013.39511
Yousefinejad, Abbas, Mazloom, Zohreh, Dabbaghmanesh, Mohammad Hossein. Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial. سامانه مدیریت نشریات علمی, 1391; 38(1): 38-43. doi: 10.30476/ijms.2013.39511

Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial

Iranian Journal of Medical Sciences
مقاله 5، دوره 38، شماره 1، خرداد 2013، صفحه 38-43    اصل مقاله (401.33 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2013.39511
نویسندگان
Abbas Yousefinejad* 1؛ Zohreh Mazloom2؛ Mohammad Hossein Dabbaghmanesh3
1Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2Department of Nutrition, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
3Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The dramatic increase in the incidence of diabetes and its associated complications require a natural and safe solution to control and delay such complications. The present study tested the hypothesis that probiotics may affect biochemical indices of diabetic patients
Methods: Thirty four types 2 diabetic patients aged between 25 to 65 years, and diagnosed with diabetes for less than 15 years were selected for this single- blinded clinical trial. Using balanced block random sampling, the patients were divided into two groups of intervention (probiotics) and placebo. Blood samples tested for baseline glucose, insulin, TG, total cholesterol, LDL-C, HDL-C, malondialdehyde, high sensitive CRP (hs-CRP) and IL-6. After six weeks of experiment, fasting blood samples were re-tested and the data obtained were analyzed using SPSS software.
Results: There were no significant differences between anthropometric data including body mass index and waist to hip ratio in placebo and treatment groups. There was no significant difference in FBS, Serum TG concentration total cholesterol and LDL-C levels between placebo and treatment groups. HDL-C levels were slightly elevated after probiotic treatment, which were not statistically significant. Insulin, MDA and IL-6 levels were reduced and high sensitive CRP hs.CRP levels were elevated, although, not statistically significant.
Conclusion: The result of this study indicates a non- significant declining trend in the level of TG, MDA and IL-6 and insulin resistance after consumption of probiotics.
کلیدواژه‌ها
Probiotic؛ Diabetes؛ Insulin resistance؛ CRP
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