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Balali-Mood, Mahdi, Kianoush, Sina, Mousavi, Seyed Reza, Shakeri, Mohammad Taghi, Dadpour, Bita, Moradi, Valiollah, Sadeghi, Mahmoud. (1391). Clinical, Toxicological, Biochemical, and Hematologic Parameters in Lead Exposed Workers of a Car Battery Industry. سامانه مدیریت نشریات علمی, 38(1), 30-37. doi: 10.30476/ijms.2013.39510
Mahdi Balali-Mood; Sina Kianoush; Seyed Reza Mousavi; Mohammad Taghi Shakeri; Bita Dadpour; Valiollah Moradi; Mahmoud Sadeghi. "Clinical, Toxicological, Biochemical, and Hematologic Parameters in Lead Exposed Workers of a Car Battery Industry". سامانه مدیریت نشریات علمی, 38, 1, 1391, 30-37. doi: 10.30476/ijms.2013.39510
Balali-Mood, Mahdi, Kianoush, Sina, Mousavi, Seyed Reza, Shakeri, Mohammad Taghi, Dadpour, Bita, Moradi, Valiollah, Sadeghi, Mahmoud. (1391). 'Clinical, Toxicological, Biochemical, and Hematologic Parameters in Lead Exposed Workers of a Car Battery Industry', سامانه مدیریت نشریات علمی, 38(1), pp. 30-37. doi: 10.30476/ijms.2013.39510
Balali-Mood, Mahdi, Kianoush, Sina, Mousavi, Seyed Reza, Shakeri, Mohammad Taghi, Dadpour, Bita, Moradi, Valiollah, Sadeghi, Mahmoud. Clinical, Toxicological, Biochemical, and Hematologic Parameters in Lead Exposed Workers of a Car Battery Industry. سامانه مدیریت نشریات علمی, 1391; 38(1): 30-37. doi: 10.30476/ijms.2013.39510

Clinical, Toxicological, Biochemical, and Hematologic Parameters in Lead Exposed Workers of a Car Battery Industry

Iranian Journal of Medical Sciences
مقاله 4، دوره 38، شماره 1، خرداد 2013، صفحه 30-37    اصل مقاله (418.29 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2013.39510
نویسندگان
Mahdi Balali-Mood* 1؛ Sina Kianoush1؛ Seyed Reza Mousavi1؛ Mohammad Taghi Shakeri2؛ Bita Dadpour1؛ Valiollah Moradi1؛ Mahmoud Sadeghi1
1Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Lead is a toxic element which causes acute, subacute or chronic poisoning through environmental and occupational exposure. The aim of this study was to investigate clinical and laboratory abnormalities of chronic lead poisoning among workers of a car battery industry.
Methods: Questionnaires and forms were designed and used to record demographic data, past medical histories and clinical manifestations of lead poisoning. Blood samples were taken to determine biochemical (using Auto Analyzer; Model BT3000) and hematologic (using Cell Counter Sysmex; Model KX21N) parameters. An atomic absorption spectrometer (Perkin-Elmer, Model 3030, USA) was used to determine lead concentration in blood and urine by heated graphite atomization technique.
Results: A total of 112 men mean age 28.78±5.17 years, who worked in a car battery industry were recruited in the present study. The most common signs/symptoms of lead poisoning included increased excitability 41.9%, arthralgia 41.0%, fatigue 40.1%, dental grey discoloration 44.6%, lead line 24.1%, increased deep tendon reflexes (DTR) 22.3%, and decreased DTR (18.7%). Blood lead concentration (BLC) was 398.95 µg/L±177.40, which was significantly correlated with duration of work (P=0.044) but not with the clinical manifestations of lead poisoning. However, BLC was significantly correlated with urine lead concentration (83.67 µg/L±49.78; r2=0.711; p <0.001), mean corpuscular hemoglobin (r=-0.280; P=0.011), mean corpuscular hemoglobin concentration (r=-0.304; P=0.006) and fasting blood sugar or FBS (r=-0.258; P=0.010).
Conclusion: Neuropsychiatric and skeletal findings were common manifestations of chronic occupational lead poisoning. BLC was significantly correlated with duration of work, urine lead concentration, two hemoglobin indices and FBS.
کلیدواژه‌ها
Lead poisoning؛ Occupational exposure؛ Biochemical markers؛ Hematologic tests
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