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Sari Aslani, Fatemeh, Safaei, Akbar, Pourjabali, Masoumeh, Momtahan, Mozhdeh. (1391). Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions. سامانه مدیریت نشریات علمی, 38(1), 15-21. doi: 10.30476/ijms.2013.39504
Fatemeh Sari Aslani; Akbar Safaei; Masoumeh Pourjabali; Mozhdeh Momtahan. "Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions". سامانه مدیریت نشریات علمی, 38, 1, 1391, 15-21. doi: 10.30476/ijms.2013.39504
Sari Aslani, Fatemeh, Safaei, Akbar, Pourjabali, Masoumeh, Momtahan, Mozhdeh. (1391). 'Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions', سامانه مدیریت نشریات علمی, 38(1), pp. 15-21. doi: 10.30476/ijms.2013.39504
Sari Aslani, Fatemeh, Safaei, Akbar, Pourjabali, Masoumeh, Momtahan, Mozhdeh. Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions. سامانه مدیریت نشریات علمی, 1391; 38(1): 15-21. doi: 10.30476/ijms.2013.39504

Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions

Iranian Journal of Medical Sciences
مقاله 2، دوره 38، شماره 1، خرداد 2013، صفحه 15-21    اصل مقاله (461.55 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2013.39504
نویسندگان
Fatemeh Sari Aslani* 1؛ Akbar Safaei1؛ Masoumeh Pourjabali1؛ Mozhdeh Momtahan2
1Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Cervical intraepithelial neoplasia (CIN) is a premalignant lesion capable of progressing to cervical cancer. Despite the existing well-defined criteria, the histomorphologic diagnosis is subject to high rates of discordance among pathologists. The aim of this study was to evaluate Ki-67 (MIB-1), CK17 and p16 INK4a (p16) markers by immunohistochemical methods in differentiating CIN from benign cervical lesions.
Methods: The present study reviewed and re-classified 77 cervical biopsies, originally diagnosed as 31 non-CIN, and 46 CIN, as 54 non-CIN, and 23 CIN based on at least two similar diagnoses. Immunostaining by Ki67, p16 and CK17 markers was performed on all cases and the results were compared with pervious and consensus diagnosis.
Results: The overall agreement between pervious and consensus diagnosis was 67.5% (Kappa=0.39, p <0.001). The sensitivity and specificity of Ki67 immunostaining were 95.6% and 85.1% respectively, while for p16 the corresponding values were 91.3% and 98.1%. The overall agreement, for both p16 and Ki67, with consensus diagnosis were significant (p <0.001). The sensitivity and specificity of CK17 negative staining in CIN detection were 39.1% and 40.7% respectively.
Conclusion: Ki67 and p16 markers are recommended as complementary tests for differentiating between dysplastic and non-dysplastic lesions. CK17 does not discriminate between immature metaplasia with and without dysplasia.
کلیدواژه‌ها
CIN؛ Ki67 (MIB-1)؛ p16 INK4a
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