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Efficacy of Topical Alpha Ointment (Containing Natural Henna) Compared to Topical Hydrocortisone (1%) in the Healing of Radiation-Induced Dermatitis in Patients with Breast Cancer: A Randomized Controlled Clinical Trial | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 2، دوره 38، شماره 4، دی 2013، صفحه 293-300 اصل مقاله (445.41 K) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| Mansour Ansari* 1؛ Farzin Dehsara2؛ Ahmad Mosalaei3؛ Shapour Omidvari1؛ Niloofar Ahmadloo1؛ Mohammad Mohammadianpanah4 | ||
| 1Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Student Research Committee, Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Shiraz Institute for Cancer Research, Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1%) in the healing of radiation-induced dermatitis in breast cancer patients. Methods: The inclusion criteria comprised newly pathologically proven, locally advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant treatments, including chest wall radiotherapy [45-50.4 Gy]) and grade 2 and/or 3 chest wall dermatitis. The exclusion criteria were comprised of any underlying disease or medications interfering with the wound healing process, previous history of chest wall radiotherapy, and concurrent use of chemotherapy. Sixty eligible patients were randomly assigned to use either topical Alpha ointment (study arm, n=30) or topical hydrocortisone cream (1%) (control arm, n=30) immediately after receiving a total dose of 45-50 Gy chest wall radiotherapy. Results: The mean radiation dose was 49.1 Gy in the control arm and 48.8 Gy in the study arm. The mean dermatitis area was 13.54 cm2 in the control arm and 17.02 cm2 in the study arm. Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1%) (P=0.001). This effect was significant in the second week (P=0.007). In addition, Alpha ointment decreased the patients’ complaints such as pain (P<0.001), pruritus (P=0.009), and discharge (P=0.010) effectively and meaningfully. Conclusion: Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1%) in our patients with breast cancer. Trial Registration Number: IRCT201206099979N1 | ||
| کلیدواژهها | ||
| Radiation-induced dermatitis؛ Hydrocortisone؛ Breast cancer؛ Radiotherapy | ||
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آمار تعداد مشاهده مقاله: 4,776 تعداد دریافت فایل اصل مقاله: 1,077 |
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