![سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی شیراز](./data/logo.png)
تعداد نشریات | 20 |
تعداد شمارهها | 1,118 |
تعداد مقالات | 10,259 |
تعداد مشاهده مقاله | 42,333,220 |
تعداد دریافت فایل اصل مقاله | 9,252,043 |
Effects of Ascorbic Acid on Serum Level of Unconjugated Estriol and Its Relationship with Preterm Premature Rupture of Membrane: A Double-Blind Randomized Controlled Clinical Trial | ||
Iranian Journal of Medical Sciences | ||
مقاله 3، دوره 38، شماره 3، آذر 2013، صفحه 227-232 اصل مقاله (346.83 K) | ||
نوع مقاله: Original Article(s) | ||
نویسندگان | ||
Mehrangiz Zamani1؛ Mohammad Taghi Goodarzi* 2؛ Navaz Sadat Lavasani1؛ Abas Khosravi3 | ||
1Department of Obstetrics and Gynecology, Hamadan University of Medical Sciences, Hamadan, Iran | ||
2Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | ||
3Production Manager, Modava Pharmaceutical Co., Tehran, Iran | ||
چکیده | ||
Background: Vitamin C is a water-soluble antioxidant that not only stimulates and protects collagen synthesis but also plays an important role in maintaining cellular integrity in a normal pregnancy. This study surveyed the effects of ascorbic acid on the serum level of unconjugated estriol and the relationship between unconjugated estriol and preterm premature rupture of membrane (PPROM).Methods: This double-blind, randomized clinical trial recruited 60 patients with predisposing factors to PPROM. The women were randomly divided into two groups of intervention and control and received vitamin C and placebo, respectively. The intervention group received 250 mg vitamin C twice a day and the controls received the placebo only. Unconjugated estriol was measured using the ELISA. All data were extracted and recorded in a checklist and compared using descriptive statistics as well as the x2, Fisher exact, and t tests.Results: The demographic data showed no difference between the two groups. The mean level of serum unconjugated estriol was significantly lower in the intervention group than in the control group (P=0.044). Also, the frequency of PPROM was lower in the intervention group, but the difference was not significant (P>0.05). Unconjugated estriol levels were not significantly different between the healthy women and the PPROM patients. Conclusion: This study demonstrated that vitamin C administration decreased unconjugated estriol levels in the patients with PPROM. The findings of this study also indicated that administration of ascorbic acid was a safe and effective method to reduce the incidence of PPROM. Alteration in unconjugated estriol is an active mediator for this effect.Trial Registration Number: IRCT201012083580N3 | ||
کلیدواژهها | ||
Unconjugated؛ Estrio؛ Vitamin C | ||
آمار تعداد مشاهده مقاله: 3,175 تعداد دریافت فایل اصل مقاله: 886 |