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Golmoghaddam, Hossein, Farjadian, Shirin, Khosropanah, Shahdad, Dehghani, Pooyan, Doroudchi, Mehrnoosh. (1397). Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis. سامانه مدیریت نشریات علمی, 15(3), 197-206. doi: 10.22034/iji.2018.39389
Hossein Golmoghaddam; Shirin Farjadian; Shahdad Khosropanah; Pooyan Dehghani; Mehrnoosh Doroudchi. "Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis". سامانه مدیریت نشریات علمی, 15, 3, 1397, 197-206. doi: 10.22034/iji.2018.39389
Golmoghaddam, Hossein, Farjadian, Shirin, Khosropanah, Shahdad, Dehghani, Pooyan, Doroudchi, Mehrnoosh. (1397). 'Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis', سامانه مدیریت نشریات علمی, 15(3), pp. 197-206. doi: 10.22034/iji.2018.39389
Golmoghaddam, Hossein, Farjadian, Shirin, Khosropanah, Shahdad, Dehghani, Pooyan, Doroudchi, Mehrnoosh. Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis. سامانه مدیریت نشریات علمی, 1397; 15(3): 197-206. doi: 10.22034/iji.2018.39389

Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis

Iranian Journal of Immunology
مقاله 4، دوره 15، شماره 3، آذر 2018، صفحه 197-206    اصل مقاله (167.95 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2018.39389
نویسندگان
Hossein Golmoghaddam1؛ Shirin Farjadian1؛ Shahdad Khosropanah2؛ Pooyan Dehghani2؛ Mehrnoosh Doroudchi* 1
1Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of the disease through presentation of self or foreign antigens to T cells. Objective: To investigate the association of HLA-DRB1 alleles with atherosclerosis in a sample of southwestern Iranians. Methods: We performed an analytical cross-sectional study involving 96 patients with atherosclerosis and 72 controls. HLA-DRB1 genotyping was performed by PCR-SSP method. Results: We observed a significantly lower frequency of DRB1*01 in patients with coronary artery atherosclerosis than in controls (4.68% vs. 13.1, P=0.0052, OR=3.09, CI 95%: 1.35-7.05). However, this allele showed a positive association with high blood pressure (P=0.009) in patients. Furthermore, DRB1*16 allele was associated with hyperlipidemia (P=0.008) in patients. Conclusion: Our results demonstrated that DRB1*01 may be a protective allele against atherosclerosis in individuals who live in southwest of Iran. The mechanism of this protection needs further investigation.
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