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Amani, Reza, Abbasnezhad, Amir, Hajiani, Eskandar, Cheraghian, Bahman, Abdoli, Zahra, Choghakhori, Razieh. (1397). Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome. سامانه مدیریت نشریات علمی, 15(3), 186-196. doi: 10.22034/iji.2018.39388
Reza Amani; Amir Abbasnezhad; Eskandar Hajiani; Bahman Cheraghian; Zahra Abdoli; Razieh Choghakhori. "Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome". سامانه مدیریت نشریات علمی, 15, 3, 1397, 186-196. doi: 10.22034/iji.2018.39388
Amani, Reza, Abbasnezhad, Amir, Hajiani, Eskandar, Cheraghian, Bahman, Abdoli, Zahra, Choghakhori, Razieh. (1397). 'Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome', سامانه مدیریت نشریات علمی, 15(3), pp. 186-196. doi: 10.22034/iji.2018.39388
Amani, Reza, Abbasnezhad, Amir, Hajiani, Eskandar, Cheraghian, Bahman, Abdoli, Zahra, Choghakhori, Razieh. Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome. سامانه مدیریت نشریات علمی, 1397; 15(3): 186-196. doi: 10.22034/iji.2018.39388

Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome

Iranian Journal of Immunology
مقاله 3، دوره 15، شماره 3، آذر 2018، صفحه 186-196    اصل مقاله (263.85 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2018.39388
نویسندگان
Reza Amani1، 2؛ Amir Abbasnezhad* 3، 4؛ Eskandar Hajiani5؛ Bahman Cheraghian6؛ Zahra Abdoli7؛ Razieh Choghakhori2
1Diabetes Research Center, Health Research Institute, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
2Food Security Research Center, Health Research Institute, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan,
3Nutritional Health Research Center, Department of Nutrition, Lorestan University of Medical Sciences, Khorramabad,
4Nutrition and Metabolic Diseases Researcher Center, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences,
5Research Center for Infectious Diseases of the Digestive System, Ahvaz Jundishapur University of Medical Sciences,
6Research Center for Infectious Diseases of Digestive System, Department of Biostatistics and Epidemiology, School of Public Health
7Department of Immunology, Faculty of medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Background: Given the variations in clinical presentation and physiopathological mechanisms in irritable bowel syndrome (IBS) subtypes, it is an acknowledged fact that the response to treatments can be disparate. Objective: To assess the effect of vitamin D on inflammatory cytokines (IL-17, IL-10, TNF-α), and biomarkers of oxidative stress (total antioxidant capacity (TAC), and malondialdehyde (MDA)) among IBS patients. Methods: A double-blind, randomized, placebo-controlled 6-month intervention study was carried out on 90 IBS patients (85 were analyzed), as defined by the Rome III criteria. Study participants were randomly assigned to receive either 50,000 IU vitamin D3 or a placebo fortnightly. Results: Vitamin D supplementation significantly reduced the IL-17 and MDA serum levels (P<0.05) and observably increased the TAC and IL-10 serum levels (P<0.05), compared with the placebo group. Comparing different bowel habit subtypes, we observed that it was only in diarrhea predominant IBS (IBS-D) that vitamin D supplementation was able to significantly reduce the serum levels of TNF-α and IL-17 (P<0.05). However, in all subtypes, IL-10 and TAC increased, while MDA decreased (P<0.05) in vitamin D group, compared to the placebo group. Conclusion: Vitamin D3 supplementation reduces the serum IL-17 and MDA levels, and augments the serum IL-10 and TAC levels in IBS patients, particularly in IBS-D subtype. Thus, the present study demonstrates the beneficial effects of vitamin D on patients with IBS-D.
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