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zhuang, yunlong, li, xixi, xu, huicong, ye, hui, sun, di, liu, xiangzhng, Ren, Guijie. (1397). Association between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir. سامانه مدیریت نشریات علمی, 15(2), 112-121. doi: 10.22034/iji.2018.39375
yunlong zhuang; xixi li; huicong xu; hui ye; di sun; xiangzhng liu; Guijie Ren. "Association between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir". سامانه مدیریت نشریات علمی, 15, 2, 1397, 112-121. doi: 10.22034/iji.2018.39375
zhuang, yunlong, li, xixi, xu, huicong, ye, hui, sun, di, liu, xiangzhng, Ren, Guijie. (1397). 'Association between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir', سامانه مدیریت نشریات علمی, 15(2), pp. 112-121. doi: 10.22034/iji.2018.39375
zhuang, yunlong, li, xixi, xu, huicong, ye, hui, sun, di, liu, xiangzhng, Ren, Guijie. Association between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir. سامانه مدیریت نشریات علمی, 1397; 15(2): 112-121. doi: 10.22034/iji.2018.39375

Association between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir

Iranian Journal of Immunology
مقاله 3، دوره 15، شماره 2، شهریور 2018، صفحه 112-121    اصل مقاله (201.28 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2018.39375
نویسندگان
yunlong zhuang1؛ xixi li2؛ huicong xu3؛ hui ye4؛ di sun5؛ xiangzhng liu6؛ Guijie Ren* 7
1Institute of Hematology, Blood center of shandong province, jinan city, China
2Taian City Central Hospital, Taian,China
3Institute of Hematology, blood center of shandong province, jinan,China
4Institute of Hematology, blood center of shandong province, jinan ,China
5Yantai Blood Bank Yantai, yantai, Chian
6Yantai Infectious Disease Hoshptol, Yantai, China
7Medical college of Shandong University, Jinan , China
چکیده
Background: Entecavir (ETV) is commonly used to treat chronic hepatitis B (CHB) in China. However, certain percentages of e-Antigen (HBeAg) positive CHB patients do not respond to ETV therapy. Objective: To investigate whether the killer immunoglobulin-like receptor (KIR) genes were associated with seroconversion in HBeAg positive CHB responder patients treated with ETV. Methods: Polymerase chain reaction with sequence-specific primers (PCR-SSP) method was performed to genotype KIR genes in 200 healthy controls and 198 HBeAg-positive CHB patients which 59 were defined as the complete response group (CRG) to the treatment with ETV and 139 were defined as null or partial response group (NPRG). Results: The frequencies of KIR2DS2 and KIR2DS3 were significantly higher (P=0.030, OR=1.57，95%CI=2.36-1.05 and P=0.018, OR=1.773，95%CI=2.77-1.13, respectively), while, the frequencies of KIR2DL3, KIR2DS1 and KIR3DS1 were significantly lower (P=0.038, OR=0.525, 95%CI=0.96-0.29,and P=0.031, OR=0.640, 95%CI =0.95-0.43, and P=0.035, OR=0.641, 95%CI =0.96-0.43, respectively) in HBeAg-positive CHB patients than those in healthy controls. The frequency of KIR2DS3 gene was significantly higher in NPRG than that in CRG (P=0.018, OR=0.402, 95%CI=0.83-0.20). The frequencies of KIR2DL3 and KIR3DS1 genes were significantly higher in CRG than those in NPRG (P=0.019, OR=3.625, 95%CI=10.83-1.21 and P=0.041, OR=1.949, 95%CI=3.65-1.04, respectively). Conclusion: Patients with KIR2DS3 might have negative responses to anti-HBV therapy with ETV and patients with KIR2DL3 and KIR3DS1 might have advantage in the therapy with ETV.
کلیدواژه‌ها
Entecavir؛ HBeAg-Positive CHB Patients؛ KIR Genes
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