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Nassar, Mogahid Yahi'a, Al-Shamahy, Hassan Abdulwahab, Al-Samawi, Abdullah Saleh, Abu Asba, Nagieb Waza'a, El-Nono, Ibrahiem Husain, Masood, Haitham Abdulwahab. (1396). Human Leukocyte Antigen Class I and II Variants in Yemeni Patients with Chronic Renal Failure. سامانه مدیریت نشریات علمی, 14(3), 240-249.
Mogahid Yahi'a Nassar; Hassan Abdulwahab Al-Shamahy; Abdullah Saleh Al-Samawi; Nagieb Waza'a Abu Asba; Ibrahiem Husain El-Nono; Haitham Abdulwahab Masood. "Human Leukocyte Antigen Class I and II Variants in Yemeni Patients with Chronic Renal Failure". سامانه مدیریت نشریات علمی, 14, 3, 1396, 240-249.
Nassar, Mogahid Yahi'a, Al-Shamahy, Hassan Abdulwahab, Al-Samawi, Abdullah Saleh, Abu Asba, Nagieb Waza'a, El-Nono, Ibrahiem Husain, Masood, Haitham Abdulwahab. (1396). 'Human Leukocyte Antigen Class I and II Variants in Yemeni Patients with Chronic Renal Failure', سامانه مدیریت نشریات علمی, 14(3), pp. 240-249.
Nassar, Mogahid Yahi'a, Al-Shamahy, Hassan Abdulwahab, Al-Samawi, Abdullah Saleh, Abu Asba, Nagieb Waza'a, El-Nono, Ibrahiem Husain, Masood, Haitham Abdulwahab. Human Leukocyte Antigen Class I and II Variants in Yemeni Patients with Chronic Renal Failure. سامانه مدیریت نشریات علمی, 1396; 14(3): 240-249.

Human Leukocyte Antigen Class I and II Variants in Yemeni Patients with Chronic Renal Failure

Iranian Journal of Immunology
مقاله 7، دوره 14، شماره 3، آذر 2017، صفحه 240-249    اصل مقاله (183 K)
نوع مقاله: Original Article
نویسندگان
Mogahid Yahi'a Nassar1؛ Hassan Abdulwahab Al-Shamahy* 2؛ Abdullah Saleh Al-Samawi3؛ Nagieb Waza'a Abu Asba4؛ Ibrahiem Husain El-Nono5؛ Haitham Abdulwahab Masood6
1Department of Clinical Pathology, Faculty of Medicine and Health Sciences, University of Science and Technology, Sana'a, Yemen
2Department of Microbiology, Faculty of Medicine and Health Sciences, Sana'a, Yemen
3Department of Pathology, Faculty of Medicine and Health Sciences, Sana'a, Yemen
4Urology and Nephrology Center, Al-Thawra General Hospital; Department of Nephrology, Faculty of Medicine and Health Sciences, Sana'a, Yemen
5Urology and Nephrology Center Al-Thawra General Hospital; Department of Urology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen
6HLA Typing Unit, Al-Thawra General Hospital, Sana'a, Yemen
چکیده
Background: Human leukocyte antigens (HLAs) are found to be significant genetic factors concerning the susceptibility of an individual to certain diseases. Objective: To determine the association between variants of class I (A and B) and class II (DRB1) HLA alleles and chronic renal failure (CRF), compared with healthy controls, in Yemen. Methods: A case-control study in the Urology and Nephrology Center at Al-Thawra University Hospital in Sana’a, Yemen was carried out between January 2013 and December 2015 and included 187 CRF patients, and 194 healthy controls visiting the same center for kidney donation. All CRF patients in the study were on haemodialysis. The control group was confirmed to be healthy following a clinical examination by specialist physicians. Among both patients and controls, HLA class I (A and B) and class II (DRB1) HLA typing was carried out by Sequence Specific Primers (SSP) polymerase chain reaction (PCR). Results: There was a significant protective function for HLA-A*30 gene (CRF 9.1% vs. con 16%, p=0.045) against CRF development. There was a high frequency of HLA-A*02, HLA-B*51 and HLA-DRB1*04 alleles in both patients and controls. Conclusion: No HLAs were located to have a significant association with genetic tendency to CRF in the current study population, however, certain HLA alleles, for instance in HLA-A*30, could be considered protective against CRF progress.
کلیدواژه‌ها
Case-Control Study؛ HLA Alleles؛ Renal Diseases؛ Yemen
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