LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,416,099
تعداد دریافت فایل اصل مقاله11,291,800
Mehraji, Zahra, Farazmand, Ali, Esteghamati, Alireza, Noshad, Sina, Sadr, Maryam, Amirzargar, Somayeh, Yekaninejad, Mir Saeed, Amirzargar, Aliakbar. (1396). Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population. سامانه مدیریت نشریات علمی, 14(3), 223-230.
Zahra Mehraji; Ali Farazmand; Alireza Esteghamati; Sina Noshad; Maryam Sadr; Somayeh Amirzargar; Mir Saeed Yekaninejad; Aliakbar Amirzargar. "Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population". سامانه مدیریت نشریات علمی, 14, 3, 1396, 223-230.
Mehraji, Zahra, Farazmand, Ali, Esteghamati, Alireza, Noshad, Sina, Sadr, Maryam, Amirzargar, Somayeh, Yekaninejad, Mir Saeed, Amirzargar, Aliakbar. (1396). 'Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population', سامانه مدیریت نشریات علمی, 14(3), pp. 223-230.
Mehraji, Zahra, Farazmand, Ali, Esteghamati, Alireza, Noshad, Sina, Sadr, Maryam, Amirzargar, Somayeh, Yekaninejad, Mir Saeed, Amirzargar, Aliakbar. Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population. سامانه مدیریت نشریات علمی, 1396; 14(3): 223-230.

Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population

Iranian Journal of Immunology
مقاله 5، دوره 14، شماره 3، آذر 2017، صفحه 223-230    اصل مقاله (74.49 K)
نوع مقاله: Original Article
نویسندگان
Zahra Mehraji1؛ Ali Farazmand2؛ Alireza Esteghamati3؛ Sina Noshad3؛ Maryam Sadr4؛ Somayeh Amirzargar4؛ Mir Saeed Yekaninejad5؛ Aliakbar Amirzargar* 4
1Department of Cellular and Molecular Biology, Kish International Campus, University of Tehran, Kish Island, Iran
2Department of Cellular and Molecular Biology, Faculty of Science, University of Tehran, Tehran, Iran
3Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
4Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Graves’ disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA) and GD among Iranians is scarce. Objective: To identify HLA polymorphisms that might confer susceptibility or protect against GD. Methods: Eighty unrelated patients with a confirmed diagnosis of GD were included in the case group. The control group consisted of 180 unrelated healthy individuals with normal thyroid function tests. The polymerase chain reaction with sequence specific primers (PCR-SSP) method was used for HLA typing. Results: Frequencies of HLA-A*68 (15.6% vs. 4.2%, p=0.004) and B*08 (8.8% vs. 2.5, p=0.030) were significantly higher in patients with GD compared with healthy controls. No patients with GD had HLA-A*33, whereas it was found in 7.0% of the controls (p=0.011). HLA-DQB1*0201 was significantly less frequent among patients with GD (15.6% vs. 26.8%, p=0.040). Additionally, patients with GD were significantly less bound to have HLA-DQA1*0201 (6.2% vs. 15.1%, p=0.045). Concerning allelic distributions, no noticeable difference was found between GD patients with and without Graves’ ophthalmopathy (p>0.05 in all cases). Conclusion: In the Iranian population, HLA-A*68 and -B*08 confer susceptibility to GD, whereas HLA-A*33, -DQB1*0201, and -DQA1*0201 appear to have protective roles.
کلیدواژه‌ها
Association؛ Graves’ Disease؛ Graves’ ophthalmopathy؛ HLA؛ Polymorphism؛ Iran
آمار
تعداد مشاهده مقاله: 1,315
تعداد دریافت فایل اصل مقاله: 1,148


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب