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Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis | ||
| Iranian Journal of Immunology | ||
| مقاله 8، دوره 14، شماره 1، خرداد 2017، صفحه 81-88 اصل مقاله (141.81 K) | ||
| نوع مقاله: Original Article | ||
| نویسندگان | ||
| Hossein Esmaeilzadeh* 1؛ Elmira Esmaeilzadeh2؛ Mohammad Faramarzi3؛ Mohammad Nabavi4؛ Mohammad Farhadi5 | ||
| 1Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Department of Internal Medicine, Division of Rheumatology,Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Department of Allergy and Immunology, Rasool-e-Akram Hospital,Tehran, Iran | ||
| 56ENT–Head and Neck Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Background: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). Objective: To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. Methods: A cross sectional multicenter study was done in two tertiary centers for allergy in Iran. Adult patients with NP were selected for the study that had been referred to allergy clinics. The oral aspirin challenge (OAC) test was performed to identify aspirin exacerbated respiratory disease (AERD) and the OFC test was used to investigate food intolerance. Atopic evaluation was performed by skin-prick tests, nasal smear and blood eosinophil count as well as serum total IgE. Results: One hundred and nineteen Iranian patients (female to male ratio 1.05) with NP were enrolled (mean age, 38 ± 11 years). Recurrence of nasal polyposis was 64.7%. OAC was performed in all cases; 43.79% cases had aspirin hypersensitivity. In addition, OFC tests determined that 69.9% of patients had salicylate food allergy. Salicylate food intolerance was significantly higher in NP cases with AERD than in aspirin tolerant patients (p<0.05). Yet, positive skin prick test was not associated with NP recurrence and AERD. Conclusion: Atopy and NSAID exacerbated respiratory disease; therefore, they can both be considered as predictors of NP recurrence. Our study also showed that salicylate food intolerance was associated with AERD in nasal polyposis. | ||
| کلیدواژه‌ها | ||
| Nasal polyposis؛ Food allergy؛ Aspirin hypersensitivity؛ Recurrence؛ Salicylate | ||
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