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Alyasin, Soheila, Amin, Reza, Fazel, Ali, Karimi, Mohammad Hossein, Nabavizadeh, Seyed Hesamedin, Esmaeilzadeh, Hossein, Babaei, Maryam. (1395). IL-23 Gene and Protein Expression in Childhood Asthma. سامانه مدیریت نشریات علمی, 14(1), 73-80.
Soheila Alyasin; Reza Amin; Ali Fazel; Mohammad Hossein Karimi; Seyed Hesamedin Nabavizadeh; Hossein Esmaeilzadeh; Maryam Babaei. "IL-23 Gene and Protein Expression in Childhood Asthma". سامانه مدیریت نشریات علمی, 14, 1, 1395, 73-80.
Alyasin, Soheila, Amin, Reza, Fazel, Ali, Karimi, Mohammad Hossein, Nabavizadeh, Seyed Hesamedin, Esmaeilzadeh, Hossein, Babaei, Maryam. (1395). 'IL-23 Gene and Protein Expression in Childhood Asthma', سامانه مدیریت نشریات علمی, 14(1), pp. 73-80.
Alyasin, Soheila, Amin, Reza, Fazel, Ali, Karimi, Mohammad Hossein, Nabavizadeh, Seyed Hesamedin, Esmaeilzadeh, Hossein, Babaei, Maryam. IL-23 Gene and Protein Expression in Childhood Asthma. سامانه مدیریت نشریات علمی, 1395; 14(1): 73-80.

IL-23 Gene and Protein Expression in Childhood Asthma

Iranian Journal of Immunology
مقاله 7، دوره 14، شماره 1، خرداد 2017، صفحه 73-80    اصل مقاله (232.71 K)
نوع مقاله: Original Article
نویسندگان
Soheila Alyasin1؛ Reza Amin1؛ Ali Fazel* 1؛ Mohammad Hossein Karimi2؛ Seyed Hesamedin Nabavizadeh1؛ Hossein Esmaeilzadeh1؛ Maryam Babaei3
1Department of Allergy and Clinical Immunology, Nemazee Hospital, University of Medical Science, Shiraz, Iran
2Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
3Department of Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Background: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adultallergic asthma has been studied. Objective: To explore IL-23 serum levels and its expression in persistent asthma compared with healthy children younger than five years old. Method: Blood samples of 40 children with mild and severe persistent asthma were compared to 34 healthy children regarding IL-23 serum levels and gene expression using enzyme-linked immunosorbentassay (ELISA) and real time quantitative polymerase chain reaction (PCR). Results: The IL-23 gene expression level was significantly different in the 25 children with mild persistent asthma and the 15 children with severe persistent asthma compared to the control group (p=0.001).There was no significant difference in IL-23 gene expression level between the two groups of patients with mild and severe persistent asthma. A significant difference was seen in IL-23 serum levels between the 25 children with persistent asthma and control group (p=0.002).Conclusion: For pre-school children with history and physical exam in favor of asthma which cannot be tested by spirometry, IL-23 serum levels may be an auxiliary biomarker for the diagnosis of asthma.
کلیدواژه‌ها
Asthma؛ Childhood؛ Interleukin-23
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