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Hosseinzadeh, Morteza, Nafar, Mohsen, Ahmadpoor, Pedram, Noorbakhsh, Farshid, Yekaninejad, Mir Saeed, Niknam, Mohammad Hossein, Amirzargar, Aliakbar. (1395). Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study. سامانه مدیریت نشریات علمی, 14(1), 24-34.
Morteza Hosseinzadeh; Mohsen Nafar; Pedram Ahmadpoor; Farshid Noorbakhsh; Mir Saeed Yekaninejad; Mohammad Hossein Niknam; Aliakbar Amirzargar. "Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study". سامانه مدیریت نشریات علمی, 14, 1, 1395, 24-34.
Hosseinzadeh, Morteza, Nafar, Mohsen, Ahmadpoor, Pedram, Noorbakhsh, Farshid, Yekaninejad, Mir Saeed, Niknam, Mohammad Hossein, Amirzargar, Aliakbar. (1395). 'Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study', سامانه مدیریت نشریات علمی, 14(1), pp. 24-34.
Hosseinzadeh, Morteza, Nafar, Mohsen, Ahmadpoor, Pedram, Noorbakhsh, Farshid, Yekaninejad, Mir Saeed, Niknam, Mohammad Hossein, Amirzargar, Aliakbar. Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study. سامانه مدیریت نشریات علمی, 1395; 14(1): 24-34.

Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study

Iranian Journal of Immunology
مقاله 3، دوره 14، شماره 1، خرداد 2017، صفحه 24-34    اصل مقاله (260.76 K)
نوع مقاله: Original Article
نویسندگان
Morteza Hosseinzadeh1؛ Mohsen Nafar2؛ Pedram Ahmadpoor3؛ Farshid Noorbakhsh1؛ Mir Saeed Yekaninejad4؛ Mohammad Hossein Niknam1؛ Aliakbar Amirzargar* 1
1Department of Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
2Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences,Tehran, Iran
4Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: The incidence of ischemic reperfusion injury (IRI) in early phase post-transplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. Objective: To investigate whether the expression of TLRs in peripheral blood mononuclear cells (PBMCs) can predict the clinical outcome of kidney allografts. Methods: We obtained blood samples from 52 renal transplant patients before transplant, and 2, 90, and 180 days post-transplantation in order to analyze the surface expressions of TLR-2 and TLR-4 on peripheral blood monocytes. The expression patterns of TLR-2 and TLR-4 were compared between patients with graft dysfunction (GD) and those with well-functioning graft (WFG). Results: Significantly different mean dynamic changes in surface expression of TLR-2, according to percentage of TLR-2+ cells, between (the GD and WFG) groups existed at most time-points before and after renal transplantation (p=0.007) with the exception of  day 2 post-transplantation. We observed significantly higher mean fluorescence intensities of TLR-2 and TLR-4 on CD14+ cells in the GD group compared to the WFG group. This finding was particularly observed 180 days post-transplantation (p=0.001). Based on TLR-2 and TLR-4 protein expression for each step, multiple logistic regression and ROC curve analysis revealed that an increase in CD14+ TLR-2+ monocytes within the 90 days  post-transplantaton was associated with increased risk of GD at 180 and 365 days post-transplantation  [odds ratio (OR)=1.27, p=0.005)]. Conclusion: Sequential monitoring of TLR-2 and TLR-4 expression patterns in peripheral blood monocytes appear to be prognostic and predictive biomarkers for early and late kidney allograft outcomes.
کلیدواژه‌ها
Allograft function؛ Kidney transplant؛ Toll-Like Receptors
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