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Tavakkol Afshari, Zeinab, Rahimi, Hamid Reza, Ehteshamfar, Seyed Morteza, Ganjali, Rashin, Tara, Fatemeh, Shapouri Moghadam, Abbas. (1395). Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia. سامانه مدیریت نشریات علمی, 13(4), 309-316.
Zeinab Tavakkol Afshari; Hamid Reza Rahimi; Seyed Morteza Ehteshamfar; Rashin Ganjali; Fatemeh Tara; Abbas Shapouri Moghadam. "Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia". سامانه مدیریت نشریات علمی, 13, 4, 1395, 309-316.
Tavakkol Afshari, Zeinab, Rahimi, Hamid Reza, Ehteshamfar, Seyed Morteza, Ganjali, Rashin, Tara, Fatemeh, Shapouri Moghadam, Abbas. (1395). 'Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia', سامانه مدیریت نشریات علمی, 13(4), pp. 309-316.
Tavakkol Afshari, Zeinab, Rahimi, Hamid Reza, Ehteshamfar, Seyed Morteza, Ganjali, Rashin, Tara, Fatemeh, Shapouri Moghadam, Abbas. Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia. سامانه مدیریت نشریات علمی, 1395; 13(4): 309-316.

Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia

Iranian Journal of Immunology
مقاله 7، دوره 13، شماره 4، اسفند 2016، صفحه 309-316    اصل مقاله (213.41 K)
نوع مقاله: Original Article
نویسندگان
Zeinab Tavakkol Afshari1؛ Hamid Reza Rahimi2؛ Seyed Morteza Ehteshamfar1؛ Rashin Ganjali1؛ Fatemeh Tara3؛ Abbas Shapouri Moghadam* 1
1Bu-Ali Research Institute, Department of Immunogenetics, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Advanced Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Women's Health Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Pre-eclampsia is the most common critical condition during pregnancy.
Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta
(IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant
women. Objective: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G-
308A), and (G-238A) in preeclemptic women northeastern Iran. Methods: This study
was conducted on 153 preeclamptic women (case group) and 150 healthy pregnant
women (control group), admitted to Ghaem and Imam Reza hospitals of Mashhad, Iran.
IL-1β (C+3954T), TNF- α (G-238A) and TNF-α (G-308A) gene polymorphisms in the
promoter region were screened by polymerase chain reaction. Data were analyzed,
using SPSS version 16.0. Results: The mean age of the participants in the case and
control groups was 28.2 ± 6.1 and 27.1 ± 6.3 years, respectively (P=0.68). The
frequency of G-308A polymorphism was significantly higher in the case group,
compared to the control group (p<0.001). However, no significant relationship was
found between IL-1β genotype and pre-eclampsia (p=0.39). The frequency of TNF- α
(G-238A) AA genotype was significantly higher in the case group, while GG genotype
was less frequently detected in the case group, compared to the control group (p<0.001
for both genotypes). Moreover, the frequencies of AA genotypes of -238 TNF-α and G-
308A polymorphisms were significantly higher in the case group, compared to the
control group (p<0.001). Conclusion: The significant correlation between inflammation
promoting genotypes of TNF-α and Pre-eclampsia is noteworthy and provides evidence
on the contribution of immune related genes in this disease.
کلیدواژه‌ها
Gene Polymorphism؛ Interleukin-1β؛ PCR-RFLP؛ Pre-eclampsia؛ Tumor necrosis Factor-α
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