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Feyzi, Reza, Boskabady, Mohammad Hossein, Seyed hosseini Tamijani, Seyedeh Masoumeh, Rafatpanah, Houshang, Rezaei, Seyed Abdolrahim. (1395). The Effect of Safranal on Th1/Th2 Cytokine Balance. سامانه مدیریت نشریات علمی, 13(4), 263-273.
Reza Feyzi; Mohammad Hossein Boskabady; Seyedeh Masoumeh Seyed hosseini Tamijani; Houshang Rafatpanah; Seyed Abdolrahim Rezaei. "The Effect of Safranal on Th1/Th2 Cytokine Balance". سامانه مدیریت نشریات علمی, 13, 4, 1395, 263-273.
Feyzi, Reza, Boskabady, Mohammad Hossein, Seyed hosseini Tamijani, Seyedeh Masoumeh, Rafatpanah, Houshang, Rezaei, Seyed Abdolrahim. (1395). 'The Effect of Safranal on Th1/Th2 Cytokine Balance', سامانه مدیریت نشریات علمی, 13(4), pp. 263-273.
Feyzi, Reza, Boskabady, Mohammad Hossein, Seyed hosseini Tamijani, Seyedeh Masoumeh, Rafatpanah, Houshang, Rezaei, Seyed Abdolrahim. The Effect of Safranal on Th1/Th2 Cytokine Balance. سامانه مدیریت نشریات علمی, 1395; 13(4): 263-273.

The Effect of Safranal on Th1/Th2 Cytokine Balance

Iranian Journal of Immunology
مقاله 3، دوره 13، شماره 4، اسفند 2016، صفحه 263-273    اصل مقاله (291.34 K)
نوع مقاله: Original Article
نویسندگان
Reza Feyzi1؛ Mohammad Hossein Boskabady* 2؛ Seyedeh Masoumeh Seyed hosseini Tamijani2؛ Houshang Rafatpanah3؛ Seyed Abdolrahim Rezaei3
1Central Laboratory of Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
2Neurogenic Inflammation Research Center, Department of Physiology, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
3Buali Institute, Immunology Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Several biological and medical benefits of Saffron, Crocus sativus
(Iridaceae), have been demonstrated. However, mechanisms of actions for purified
constituents are greatly unknown. Objective: To examine the effects of Safranal, a main
constituent of Saffron stigma, on cell viability and cytokine profile of peripheral blood
mononuclear cells (PBMC) were examined. Methods: Effects of Safranal at 0.1, 0.5
and 1 mM concentrations were evaluated on cell viability and production of interleukin
4 (IL-4), IL-10 and interferon-γ (IFN-γ) from non-stimulated and phytohemagglutinin
(PHA) stimulated PBMCs, compared to 0.1 mM dexamethasone and saline. Results: In
stimulated cells, different concentrations of Safranal caused significant decrease of
lymphocytes viability (p<0.001 for all concentrations). All concentrations of Safranal
inhibited IFN-γ and IL-10 secretion in stimulated cells (p<0.01). In addition, high
concentration of Safranal significantly decreased cell viability of non-stimulated
PBMCs (p<0.001). The effect of 1 mM Safranal on IL-4 secretion was less than
dexamethasone (p<0.05). Safranal showed a stimulatory effect on IFN-γ secretion in
non-stimulated cells. The IFN-γ/IL-4 ratio at the presence of two higher Safranal
concentrations both in non-stimulated and stimulated cells were significantly higher
than those of control and PHA stimulated groups, respectively (p<0.05). Conclusion:
The IFN-γ/IL-4 ratio increases in the presence of Safranal which indicates an effect on
Th1/Th2 balance. Therefore, Safranal may have therapeutic effects in inflammatory
diseases associated with Th1/Th2 imbalance.
کلیدواژه‌ها
Cell Viability؛ Cytokine؛ Safranal؛ Th1؛ Th2
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