پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شمارهها | 1,095 |
| تعداد مقالات | 10,041 |
| تعداد مشاهده مقاله | 28,006,545 |
| تعداد دریافت فایل اصل مقاله | 7,808,123 |
Immunogenicity of 23-Valent Pneumococcal Vaccine in Children with Systemic Lupus Erythematosus | ||
| Iranian Journal of Immunology | ||
| مقاله 6، دوره 13، شماره 3، آذر 2016، صفحه 204-219 اصل مقاله (307.16 K) | ||
| نوع مقاله: Original Article | ||
| نویسندگان | ||
| Soheila Alyasin* 1؛ Marzieh Adab* 2؛ Asieh Hosseinpour2؛ Reza Amin1؛ Maryam Babaei2 | ||
| 1Allergy Research Center, Department of Pediatrics, Division of Clinical Immunology and Allergy | ||
| 2Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE. Objective: To investigate humoral immunity and specific-antibody formation in response to a 23-valent polysaccharide pneumococcal vaccination in SLE children and asthmatic control group. Method: The case and control groups consisted of 30 children with the mean age of 13 years who were matched by sex and age. Anti-pneumococcal antibody titers were determined using Enzyme-Linked Immunosorbent Assay (ELISA) before the vaccination with the 23-valent pneumococcal vaccine and 3 weeks later in both groups. Also the correlation between anti-pneumococcal antibody titer and different factors including age, sex, lupus activity, disease duration, medications, history of recurrent infections, and laboratory data were investigated. Results: Both groups showed significant increases in anti-pneumococcal antibody level after vaccination (p≤0.001). The increase in antibody level were almost the same in both groups (p≥0.05) such that 77.7% of SLE children and 86.2% of control children showed at least 2-fold increase in anti-pneumococcal antibody titer following immunization. Significant correlations were seen between the level of post-immunization anti-pneumococcal antibody with the age of children with SLE (p=0.02) and their age of disease onset (p=0.02). Conclusion: It is concluded that pneumococcal vaccination is generally immunogenic in children with SLE. However, a small group of patients show impaired response to the vaccine. | ||
| کلیدواژهها | ||
| 23-Valent Pneumococcal Vaccine؛ Anti-Pneumococcal Antibody؛ children؛ Immunogenicity؛ Systemic Lupus Erythematosus (SLE) | ||
|
آمار تعداد مشاهده مقاله: 1,418 تعداد دریافت فایل اصل مقاله: 1,547 |
||