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Alyasin, Soheila, Adab, Marzieh, Hosseinpour, Asieh, Amin, Reza, Babaei, Maryam. (1395). Immunogenicity of 23-Valent Pneumococcal Vaccine in Children with Systemic Lupus Erythematosus. سامانه مدیریت نشریات علمی, 13(3), 204-219.
Soheila Alyasin; Marzieh Adab; Asieh Hosseinpour; Reza Amin; Maryam Babaei. "Immunogenicity of 23-Valent Pneumococcal Vaccine in Children with Systemic Lupus Erythematosus". سامانه مدیریت نشریات علمی, 13, 3, 1395, 204-219.
Alyasin, Soheila, Adab, Marzieh, Hosseinpour, Asieh, Amin, Reza, Babaei, Maryam. (1395). 'Immunogenicity of 23-Valent Pneumococcal Vaccine in Children with Systemic Lupus Erythematosus', سامانه مدیریت نشریات علمی, 13(3), pp. 204-219.
Alyasin, Soheila, Adab, Marzieh, Hosseinpour, Asieh, Amin, Reza, Babaei, Maryam. Immunogenicity of 23-Valent Pneumococcal Vaccine in Children with Systemic Lupus Erythematosus. سامانه مدیریت نشریات علمی, 1395; 13(3): 204-219.

Immunogenicity of 23-Valent Pneumococcal Vaccine in Children with Systemic Lupus Erythematosus

Iranian Journal of Immunology
مقاله 6، دوره 13، شماره 3، آذر 2016، صفحه 204-219    اصل مقاله (307.16 K)
نوع مقاله: Original Article
نویسندگان
Soheila Alyasin* 1؛ Marzieh Adab* 2؛ Asieh Hosseinpour2؛ Reza Amin1؛ Maryam Babaei2
1Allergy Research Center, Department of Pediatrics, Division of Clinical Immunology and Allergy
2Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE.
Objective: To investigate humoral immunity and specific-antibody formation in response to a 23-valent polysaccharide pneumococcal vaccination in SLE children and asthmatic control group.
Method: The case and control groups consisted of 30 children with the mean age of 13 years who were matched by sex and age. Anti-pneumococcal antibody titers were determined using Enzyme-Linked Immunosorbent Assay (ELISA) before the vaccination with the 23-valent pneumococcal vaccine and 3 weeks later in both groups. Also the correlation between anti-pneumococcal antibody titer and different factors including age, sex, lupus activity, disease duration, medications, history of recurrent infections, and laboratory data were investigated.
Results: Both groups showed significant increases in anti-pneumococcal antibody level after vaccination (p≤0.001). The increase in antibody level were almost the same in both groups (p≥0.05) such that 77.7% of SLE children and 86.2% of control children showed at least 2-fold increase in anti-pneumococcal antibody titer following immunization. Significant correlations were seen between the level of post-immunization anti-pneumococcal antibody with the age of children with SLE (p=0.02) and their age of disease onset (p=0.02).
Conclusion: It is concluded that pneumococcal vaccination is generally immunogenic in children with SLE. However, a small group of patients show impaired response to the vaccine.
کلیدواژه‌ها
23-Valent Pneumococcal Vaccine؛ Anti-Pneumococcal Antibody؛ children؛ Immunogenicity؛ Systemic Lupus Erythematosus (SLE)
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