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Cytokine Production in Hymenolepis Nana Infection | ||
| Iranian Journal of Immunology | ||
| مقاله 7، دوره 4، شماره 4، اسفند 2007، صفحه 236-240 اصل مقاله (163.4 K) | ||
| نوع مقاله: Original Article | ||
| نویسندگان | ||
| Aboulghasem Ajami؛ Alireza Rafiei* | ||
| Department of Immunology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran | ||
| چکیده | ||
| Background: Although many experimental studies provide convincing evidence that type II immunity is protective against helminths, recent data in mice demonstrate that Th1 is also impor-tant in some cestodes like Hymenolepis nana. Objective: To identify the role of Th1 and Th2 lymphocytes in immunity against H. nana, the levels of IL-12, IFNγ, IL-5, and IL-13 were de-termined in serum of humans infected with this cestode. Methods: A total of 31 patients (case) with H. nana infection and 30 clinically healthy individuals (control) was included in this study. Measurements of IL-12, IFNγ, IL-13 and IL-5 in serum samples were performed by solid-phase sandwich enzyme linked immunosorbant assay. Differential leukocyte count was also done. T test, Mann Whitney U test and Wilcoxan W test were used for data analysis. Results: The mean concentrations of IFNγ, IL-12 and IL-5 in the sera of patients with H. nana infection were higher than the control group, but only the differences between the concentrations of IFNγ (p<0.001) and IL-13 (p<0.05) in the two groups were significant. There was an increase in the percentage of monocytes, eosinophils and lymphocytes in patients when compared to the controls, but this increase was not significant. Conclusion: Results from the present study in humans are in agree-ment with experimental studies in animals in which both Th1 and Th2 responses occur in H. nana infection. | ||
| کلیدواژهها | ||
| Hymenolepis nana؛ Cytokines؛ Th1 and Th2 | ||
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