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Hosseini, Reza Farid, Jabbari Azad, Farahzad, Talaee, Ali, Miri, Sara, Mokhber, Naghme, Farid Hosseini, Farhad, Esmaeili, Habibollah, Mahmoudi, Mahmoud, Rafatpanah, Hoshang, Mohammadi, Mohammadreza. (1385). Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD). سامانه مدیریت نشریات علمی, 4(1), 38-43.
Reza Farid Hosseini; Farahzad Jabbari Azad; Ali Talaee; Sara Miri; Naghme Mokhber; Farhad Farid Hosseini; Habibollah Esmaeili; Mahmoud Mahmoudi; Hoshang Rafatpanah; Mohammadreza Mohammadi. "Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD)". سامانه مدیریت نشریات علمی, 4, 1, 1385, 38-43.
Hosseini, Reza Farid, Jabbari Azad, Farahzad, Talaee, Ali, Miri, Sara, Mokhber, Naghme, Farid Hosseini, Farhad, Esmaeili, Habibollah, Mahmoudi, Mahmoud, Rafatpanah, Hoshang, Mohammadi, Mohammadreza. (1385). 'Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD)', سامانه مدیریت نشریات علمی, 4(1), pp. 38-43.
Hosseini, Reza Farid, Jabbari Azad, Farahzad, Talaee, Ali, Miri, Sara, Mokhber, Naghme, Farid Hosseini, Farhad, Esmaeili, Habibollah, Mahmoudi, Mahmoud, Rafatpanah, Hoshang, Mohammadi, Mohammadreza. Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD). سامانه مدیریت نشریات علمی, 1385; 4(1): 38-43.

Assessment of the Immune System Activity in Iranian Patients with Major Depression Disorder (MDD)

Iranian Journal of Immunology
مقاله 5، دوره 4، شماره 1، خرداد 2007، صفحه 38-43    اصل مقاله (136.58 K)
نوع مقاله: Original Article
نویسندگان
Reza Farid Hosseini* 1؛ Farahzad Jabbari Azad1؛ Ali Talaee1؛ Sara Miri1؛ Naghme Mokhber1؛ Farhad Farid Hosseini2؛ Habibollah Esmaeili1؛ Mahmoud Mahmoudi1؛ Hoshang Rafatpanah1؛ Mohammadreza Mohammadi2
1Bu-Ali Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Rozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Major Depression Disorder (MDD) is a common disorder with preva-lence of 15% among men and up to 25% among women. In recent years the association of immune system alterations and MDD has been investigated. Assessments of immu-nologic and inflammatory responses in these patients enhance our knowledge of the eti-ology and pathogenesis of this disease.
Objective: To investigate the changes in immu-noglobulin and cytokine serum levels and lymphocyte subsets in patients with MDD.
Methods: We studied 37 adult patients with MDD, diagnosed based on DSM-IV diag-nostic criteria, and 15 healthy controls matched with the patients. Plasma concentration of interleukin-4 (IL-4), IL-10, TNF α, and IFN γ were measured by ELISA and serum immunoglobulins by SRID. Total number of NK cells (CD16 and CD56), B cells (CD19), and T cells (CD8, CD4, and CD3) were determined by flow cytometry.
Results: We found no significant differences in plasma concentration of IL-4, IL-10, TNF-α, IFN-γ, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects.
Conclusion: We conclude that in our patients, there were no significant differences in immune system ac-tivity between MDD patients and controls.
کلیدواژه‌ها
Major Depression؛ Cytokines؛ Immunoglobulin
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