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Ahmadi, Kazem, Riazipour, Majid. (1387). Effects of T-2 Toxin on Cytokine Produc-tion by Mice Peritoneal Macrophages and Lymph Node T-Cells. سامانه مدیریت نشریات علمی, 5(3), 177-180.
Kazem Ahmadi; Majid Riazipour. "Effects of T-2 Toxin on Cytokine Produc-tion by Mice Peritoneal Macrophages and Lymph Node T-Cells". سامانه مدیریت نشریات علمی, 5, 3, 1387, 177-180.
Ahmadi, Kazem, Riazipour, Majid. (1387). 'Effects of T-2 Toxin on Cytokine Produc-tion by Mice Peritoneal Macrophages and Lymph Node T-Cells', سامانه مدیریت نشریات علمی, 5(3), pp. 177-180.
Ahmadi, Kazem, Riazipour, Majid. Effects of T-2 Toxin on Cytokine Produc-tion by Mice Peritoneal Macrophages and Lymph Node T-Cells. سامانه مدیریت نشریات علمی, 1387; 5(3): 177-180.

Effects of T-2 Toxin on Cytokine Produc-tion by Mice Peritoneal Macrophages and Lymph Node T-Cells

Iranian Journal of Immunology
مقاله 6، دوره 5، شماره 3، آذر 2008، صفحه 177-180    اصل مقاله (224.84 K)
نوع مقاله: Short Paper
نویسندگان
Kazem Ahmadi* ؛ Majid Riazipour
Research Center of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده
Background: T-2 toxin is a mycotoxin of type A trichothecenes produced by several fungal genera such as Fusarium species. Mycotoxins can affect both cell mediated and humoral immune compartments.
Objective: The purpose of this study was to investi-gate the effect of T-2 toxin on cytokine production by mouse peritoneal macrophages and lymph node T cells.
Methods: Mouse peritoneal macrophages and lymph node T cells were isolated and treated with different concentrations of T-2 toxin and incubated at 370C and 5% CO2 in air for 48 hours. Cell free media were removed and used for cy-tokine assay by an ELISA method.
Results: T-2 toxin significantly reduced IL-1β re-lease in a concentration dependent manner (p<0.005, p<0.001). Interleukin-12 and TNF-α production were significantly increased in response to 0.001ng/ml, 0.01ng/ml and 0.1ng/ml of T-2 toxin (p<0.001). However, T-2 toxin at higher concentrations rang-ing from 1ng/ml to 100ng/ml, reduced both IL-12 (p<0.001) and TNF-α production (p<0.005, p<0.05). The effects of T-2 toxin on lymph node T cells showed that IL-4 and IL-10 release was decreased in a concentration dependent manner (all with p<0.01). T-2 toxin at concentrations between 1ng/ml and 100ng/ml reduced the release of both IL-2 and IFN-γ (p<0.05, p<0.001).
Conclusion: The results suggest that T-2 toxin at low concentrations can highly induce secretion of IL-12, TNF-α, IFN-γ and IL-2 and it may be used as a positive immunomodulator in the human model.
کلیدواژه‌ها
T-2 toxin؛ IL-1β؛ IL-12؛ TNF-α؛ IL-2؛ IFN-γ
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