LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,089
تعداد مقالات9,995
تعداد مشاهده مقاله26,408,981
تعداد دریافت فایل اصل مقاله7,284,359
Amirzargar, Ali Akbar, Mohseni, Nilufar, Shokrgozar, Mohammad Ali, Arjang, Zohreh, Ahmadi, Nahid, Yousefi Behzadi, Manijeh, Amanzadeh, Amir, Shokri, Fazel. (1387). HLA-DRB1, DQA1 and DQB1 Alleles and Hap-lotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombi-nant Hepatitis B Vaccine. سامانه مدیریت نشریات علمی, 5(2), 92-99. doi: 10.22034/iji.2008.17105
Ali Akbar Amirzargar; Nilufar Mohseni; Mohammad Ali Shokrgozar; Zohreh Arjang; Nahid Ahmadi; Manijeh Yousefi Behzadi; Amir Amanzadeh; Fazel Shokri. "HLA-DRB1, DQA1 and DQB1 Alleles and Hap-lotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombi-nant Hepatitis B Vaccine". سامانه مدیریت نشریات علمی, 5, 2, 1387, 92-99. doi: 10.22034/iji.2008.17105
Amirzargar, Ali Akbar, Mohseni, Nilufar, Shokrgozar, Mohammad Ali, Arjang, Zohreh, Ahmadi, Nahid, Yousefi Behzadi, Manijeh, Amanzadeh, Amir, Shokri, Fazel. (1387). 'HLA-DRB1, DQA1 and DQB1 Alleles and Hap-lotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombi-nant Hepatitis B Vaccine', سامانه مدیریت نشریات علمی, 5(2), pp. 92-99. doi: 10.22034/iji.2008.17105
Amirzargar, Ali Akbar, Mohseni, Nilufar, Shokrgozar, Mohammad Ali, Arjang, Zohreh, Ahmadi, Nahid, Yousefi Behzadi, Manijeh, Amanzadeh, Amir, Shokri, Fazel. HLA-DRB1, DQA1 and DQB1 Alleles and Hap-lotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombi-nant Hepatitis B Vaccine. سامانه مدیریت نشریات علمی, 1387; 5(2): 92-99. doi: 10.22034/iji.2008.17105

HLA-DRB1, DQA1 and DQB1 Alleles and Hap-lotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombi-nant Hepatitis B Vaccine

Iranian Journal of Immunology
مقاله 3، دوره 5، شماره 2، شهریور 2008، صفحه 92-99    اصل مقاله (186.29 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2008.17105
نویسندگان
Ali Akbar Amirzargar1، 2؛ Nilufar Mohseni1؛ Mohammad Ali Shokrgozar1؛ Zohreh Arjang1؛ Nahid Ahmadi1؛ Manijeh Yousefi Behzadi1؛ Amir Amanzadeh1؛ Fazel Shokri* 1، 3
1National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
2Deartment of Immunology, Faculty of Medicine, Medical Sciences/University of Tehran, Tehran, Iran
3Department of Immunology, School of Public Health, Medical Sciences/University of Tehran, Tehran, Iran
چکیده
Background: Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (HLA) class-II alleles or haplotypes.
Objectives: The present study was under-taken to determine the frequency of HLA class-II alleles in Iranian healthy adult re-sponders and non-responders to HB vaccine.
Methods: Twelve non-responders (anti-HBs antibody<10 IU/L) and 46 responders (anti-HBs antibody>100 IU/L) were tissue typed for HLA class-II. HLA-DRB1, DQB1 and DQA1 alleles were determined using polymerase chain reaction based on sequence specific primers (PCR-SSP) technique. Accessibility to excess amount of genomic DNA was possible using Epstein-Barr virus (EBV)-transformed B-cells established from all vaccinees.
Results: Our results demon-strated increased frequencies of HLA- DRB1*07, DRB1*03, DRB1*04, DQB1*0201, DQA1*0201 alleles and HLA- DRB1*07/DQB1*0201/DQA1*0201 and DRB1*04/DQB1*0302/DQA1*03011 haplotypes in the non-responder group. Com-parison between responders and non-responders revealed only a significant difference for DQB1*0201 allele (p<0.05).
Conclusion: These findings confirm the association of certain HLA alleles and haplotypes with the lack of antibody response to HB vaccine in an Iranian population.
کلیدواژه‌ها
Human Leukocyte Antigen؛ Hepatitis B Virus؛ Vaccination؛ Allele؛ Haplotype؛ Iranian
آمار
تعداد مشاهده مقاله: 952
تعداد دریافت فایل اصل مقاله: 966


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب