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Immunophenotypic Characterization of the Leukemic B-cells from Iranian Patients with Chronic Lymphocytic Leukemia: Association between CD38 Expression and Disease Progression | ||
| Iranian Journal of Immunology | ||
| مقاله 2، دوره 5، شماره 1، خرداد 2008، صفحه 25-35 اصل مقاله (493.26 K) | ||
| نوع مقاله: Original Article | ||
| نویسندگان | ||
| Mohammad Hojjat Farasangi1؛ Mahmood Jeddi-Tehrani2، 3؛ Seyed Mohsen Razavi4؛ Ramazan Ali Sharifian5؛ Ahmad Shamsian Khoramabadi4؛ Hojatollah Rabbani2، 3؛ Fazel Shokri* 1، 6 | ||
| 1Department of Immunology, School of Public Health, Medical Sciences /Tehran University, Tehran, Iran | ||
| 2Immune and Gene Therapy Lab, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden | ||
| 3Monoclonal Antibody Research Center, Avesina Research Institute | ||
| 4Clinic of Hematology and Oncology, Firozgar Hospital, Faculty of Medicine, Iran University of Medical Sciences | ||
| 5Clinic of Hematology and Oncology, Vali-Asr Hospital, Faculty of Medicine, Medical Sciences/ University of Tehran | ||
| 6National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran | ||
| چکیده | ||
| Background: Patients with B-cell chronic lymphocytic leukemia (B-CLL) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome. Recent immunophenotypic stud-ies performed mainly in Western populations have demonstrated the prognostic value of CD38 and ZAP-70 expression in B-CLL. Objectives: To investigate the expression pat-tern of a variety of membrane antigens on leukemic cells from Iranian patients with CLL and to find out if there are any differences in the expression of these markers between in-dolent and progressive groups. Methods: In the present study, peripheral blood samples from 87 Iranian patients with B-CLL were analysed by flow cytometry. Results: In all cases, the neoplastic cells displayed B-CLL phenotype (CD5+/CD19+/sIg+). The vast ma-jority of the cases expressed CD23, but failed to stain for CD3 or CD14. The leukemic cells of most patients expressed CD27 (84/87, 95.4%) and CD45RO (74/87, 83.9%) molecules, suggesting a memory B-cell phenotype. Comparison between the indolent (n=42) and progressive (n=37) patients revealed significantly higher frequency and inten-sity of CD38 expression in progressive group (40.5%) compared to indolent (11.9%) pa-tients (p<0.05). None of the other membrane antigens were differentially expressed in these two groups of patients. Conclusion: Our results obtained in an Asian ethnic popula-tion confirm and extend previous findings obtained from Western populations regarding the association of CD38 expression and disease progression in B-CLL. | ||
| کلیدواژهها | ||
| Immunophenotyping؛ B-CLL؛ Indolent؛ Progressive؛ CD38 | ||
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