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Noori, Shokoofe, Taghikhani, Mohammad, M. Hassan, Zuhair, Allameh, Abdolamir, Mostafaei, Ali. (1388). Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells. سامانه مدیریت نشریات علمی, 6(4), 216-224.
Shokoofe Noori; Mohammad Taghikhani; Zuhair M. Hassan; Abdolamir Allameh; Ali Mostafaei. "Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells". سامانه مدیریت نشریات علمی, 6, 4, 1388, 216-224.
Noori, Shokoofe, Taghikhani, Mohammad, M. Hassan, Zuhair, Allameh, Abdolamir, Mostafaei, Ali. (1388). 'Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells', سامانه مدیریت نشریات علمی, 6(4), pp. 216-224.
Noori, Shokoofe, Taghikhani, Mohammad, M. Hassan, Zuhair, Allameh, Abdolamir, Mostafaei, Ali. Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells. سامانه مدیریت نشریات علمی, 1388; 6(4): 216-224.

Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells

Iranian Journal of Immunology
مقاله 7، دوره 6، شماره 4، اسفند 2009، صفحه 216-224    اصل مقاله (297.51 K)
نوع مقاله: Original Article
نویسندگان
Shokoofe Noori1؛ Mohammad Taghikhani1؛ Zuhair M. Hassan* 2؛ Abdolamir Allameh1؛ Ali Mostafaei3
1Department of Biochemistry
2Immunology, Tarbiat Modares University, Tehran, Iran
3Department of Immunology, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Background: Artemisia diffusa contains a new type of sesquiterpene lactone with an endoperoxide group (Tehranolide).
Objective: Due to the existing similarity between the structures of Tehranolide and Artemisinin, it was hypothesized that Tehranolide would have similar effects as Artemisinin. In this study, the immunotherapeutic effec-tiveness of Tehranolide was investigated by direct intra-tumoral injection.
Methods: Tehranolide was purified from Artemisia diffusa, and its effect on the tumor volume was investigated. The splenocyte proliferation, shifting of cytokine profile, and the presence of naturally-occurring CD4+CD25+Foxp3+ Treg cells were assessed to describe the anti-tumor immune response.
Results: Analysis of immune response showed that, intra-tumoral injection of Tehranolide decreased the rate of tumor growth compared to control group. Furthermore, the proliferative response of mice treated with Tehranolide was en-hanced. In comparison with the control group, production of both IL-4 and IFN-γ was in-duced (p<0.05). The results indicated a decrease in tumor CD4+CD25+Foxp3+ T lym-phocytes in the Tehranolide-treated group compared to the control group.
Conclusion: Treatment of tumors with Tehranolide attenuated CD4+CD25+Foxp3+ Treg cell-mediated immune suppression and elicited a persistent anti-tumor immunity against can-cer.
کلیدواژه‌ها
Tehranolide؛ T Regulatory Cell؛ IFN-γ؛ IL-4
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