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Sudhakar, Natarajan, Karunakaran Nancy, Nirmala, Raghavan Rajalekshmy, Kamalalayam, Rajkumar, Thangarajan. (1388). Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia. سامانه مدیریت نشریات علمی, 6(3), 141-146.
Natarajan Sudhakar; Nirmala Karunakaran Nancy; Kamalalayam Raghavan Rajalekshmy; Thangarajan Rajkumar. "Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia". سامانه مدیریت نشریات علمی, 6, 3, 1388, 141-146.
Sudhakar, Natarajan, Karunakaran Nancy, Nirmala, Raghavan Rajalekshmy, Kamalalayam, Rajkumar, Thangarajan. (1388). 'Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia', سامانه مدیریت نشریات علمی, 6(3), pp. 141-146.
Sudhakar, Natarajan, Karunakaran Nancy, Nirmala, Raghavan Rajalekshmy, Kamalalayam, Rajkumar, Thangarajan. Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia. سامانه مدیریت نشریات علمی, 1388; 6(3): 141-146.

Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia

Iranian Journal of Immunology
مقاله 4، دوره 6، شماره 3، آذر 2009، صفحه 141-146    اصل مقاله (189.54 K)
نوع مقاله: Original Article
نویسندگان
Natarajan Sudhakar1، 2؛ Nirmala Karunakaran Nancy* 1؛ Kamalalayam Raghavan Rajalekshmy3؛ Thangarajan Rajkumar1
1Dept of Molecular Oncology
2Department of Biotechnology, Dr.MGR Educational and Research Institute University, Maduravoyal, Chennai 600 095,Tamil Nadu, India
3Dept of Hematology and Immunology, Cancer Institute (WIA), 38, Sardar Patel Road, Chennai 600036
چکیده
Background: Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) oc-curs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a par-ticular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic Antigen CD10 is the marker for common-ALL.
Objective: This study was aimed to examine the diversity of T-cell receptor Gamma (TCRG) and T-cell receptor Delta (TCRD) gene rearrangements in South Indian Common-ALL patients.
Methods: Clonality of TCRG and TCRD was studied in 52 cases (pediatric=41 and adolescents and young adults=11) of common-ALL. TCRG and TCRD gene rearrangements were amplified by PCR and the clonality was assessed by Heteroduplex analysis of amplified prod-ucts.
Results: In pediatric common-ALL, clonal TCRG and TCRD gene rearrange-ments were detected in 19 (46.3%) and 18 (43.9%) cases respectively. In adolescents and young adults (AYA), TCRG was rearranged in 8 (72.7%) cases and TCRD was rearranged in 4 (36.3%) cases. In the present study of common-ALL, the frequency of a TCRG rearrangement VγII-Jγ1.3/2.3 was significantly high in AYA compared to pediatric (36.3% vs 4.8%; p<0.025). Thus, VγII-Jγ1.3/2.3 was highly diverse in AYA compared to pediatric. That shows the difference in biology of the disease be-tween pediatric and AYA in South Indian population.
Conclusion: The reason for the high frequency of VγII-Jγ1.3/2.3 in AYA of common-ALL in South Indian popu-lation in connection with unknown infectious agents or environmental carcinogens needs to be evaluated further.
کلیدواژه‌ها
TCR؛ ALL؛ Heteroduplex Analysis
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