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Yousefipour, Gholam-Ali, Salami, Zahra, Farjadian, Shirin. (1388). Association of HLA-DQA1*0101/2 and DQB1*0502 with Myasthenia Gravis in Southern Iranian Patients. سامانه مدیریت نشریات علمی, 6(2), 99-102.
Gholam-Ali Yousefipour; Zahra Salami; Shirin Farjadian. "Association of HLA-DQA1*0101/2 and DQB1*0502 with Myasthenia Gravis in Southern Iranian Patients". سامانه مدیریت نشریات علمی, 6, 2, 1388, 99-102.
Yousefipour, Gholam-Ali, Salami, Zahra, Farjadian, Shirin. (1388). 'Association of HLA-DQA1*0101/2 and DQB1*0502 with Myasthenia Gravis in Southern Iranian Patients', سامانه مدیریت نشریات علمی, 6(2), pp. 99-102.
Yousefipour, Gholam-Ali, Salami, Zahra, Farjadian, Shirin. Association of HLA-DQA1*0101/2 and DQB1*0502 with Myasthenia Gravis in Southern Iranian Patients. سامانه مدیریت نشریات علمی, 1388; 6(2): 99-102.

Association of HLA-DQA1*0101/2 and DQB1*0502 with Myasthenia Gravis in Southern Iranian Patients

Iranian Journal of Immunology
مقاله 6، دوره 6، شماره 2، شهریور 2009، صفحه 99-102    اصل مقاله (219.03 K)
نوع مقاله: Short Communication
نویسندگان
Gholam-Ali Yousefipour1؛ Zahra Salami1؛ Shirin Farjadian* 2، 3
1Department of Neurology
2Department of Immunology
3Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Myasthenia gravis is an autoimmune disorder of neuromuscular junction characterized by skeletal muscle weakness and fatigability. Different genes may control the induction and clinical presentation of this disease. Various HLA alleles are reported as predisposing or protective genetic elements in myasthenia gravis.
Objective: The aim of this study was to investigate the probable association between HLA-DQ alleles and myasthenia gravis in southern Iranian patients.
Methods: HLA-DQA1 and DQB1 alleles were determined in 104 sporadic patients with myasthenia gravis using polymerase chain reaction - restriction fragment length polymorphism method and the results were compared to 816 healthy controls.
Results: HLA-DQA1*0101/2 (39.4%) and DQB1*0502 (21.6%) were the most frequent alleles in southern Iranian patients with myasthenia gravis. These alleles revealed positive associations with the disease with relative risks of 1.69 and 2.41, respectively. The most common haplotype was DQA1*0101/2-DQB1*0502 in these patients.
Conclusion: According to the results of this study, DQA1*0101/2 and DQB1*0502 alleles might be considered as predisposing genetic factors to myasthenia gravis while DQA1*0501, DQB1*0301 and *0602/3 show protective roles against this disease.
کلیدواژه‌ها
HLA-DQA؛ HLA-DQB؛ Myasthenia gravis
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