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Fouladi, Salomeh, Adib, Minoo, Salehi, Mansoor, Karimzadeh, Hadi, Bakhshiani, Zahra, Ostadi, Vajiheh. (1387). Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran. سامانه مدیریت نشریات علمی, 6(1), 49-54.
Salomeh Fouladi; Minoo Adib; Mansoor Salehi; Hadi Karimzadeh; Zahra Bakhshiani; Vajiheh Ostadi. "Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran". سامانه مدیریت نشریات علمی, 6, 1, 1387, 49-54.
Fouladi, Salomeh, Adib, Minoo, Salehi, Mansoor, Karimzadeh, Hadi, Bakhshiani, Zahra, Ostadi, Vajiheh. (1387). 'Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran', سامانه مدیریت نشریات علمی, 6(1), pp. 49-54.
Fouladi, Salomeh, Adib, Minoo, Salehi, Mansoor, Karimzadeh, Hadi, Bakhshiani, Zahra, Ostadi, Vajiheh. Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran. سامانه مدیریت نشریات علمی, 1387; 6(1): 49-54.

Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran

Iranian Journal of Immunology
مقاله 7، دوره 6، شماره 1، خرداد 2009، صفحه 49-54    اصل مقاله (293.74 K)
نوع مقاله: Short Paper
نویسندگان
Salomeh Fouladi1؛ Minoo Adib* 1؛ Mansoor Salehi2؛ Hadi Karimzadeh3؛ Zahra Bakhshiani1؛ Vajiheh Ostadi1
1Department of Immunology
2Department of Genetics and Molecular Biology
3Department of Rheumatology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups.
Objective: The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran).
Methods: Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLAB* 27 subtypes were determined by PCR-SSP.
Results: Forty patients (66.7%) and 17 controls (3.95%) were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls.
Conclusion: Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnicgroup studies.
کلیدواژه‌ها
Ankylosing Spondylitis؛ HLA-B27؛ PCR
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