LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,520
تعداد مشاهده مقاله45,480,564
تعداد دریافت فایل اصل مقاله11,299,292
Gorgian Mohammadi, Masumeh, Bamdad, Taravat, Parsania, Masoud, Hashemi, Hamid Reza, Puyanfard, Somayeh. (1387). Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity. سامانه مدیریت نشریات علمی, 6(1), 22-27.
Masumeh Gorgian Mohammadi; Taravat Bamdad; Masoud Parsania; Hamid Reza Hashemi; Somayeh Puyanfard. "Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity". سامانه مدیریت نشریات علمی, 6, 1, 1387, 22-27.
Gorgian Mohammadi, Masumeh, Bamdad, Taravat, Parsania, Masoud, Hashemi, Hamid Reza, Puyanfard, Somayeh. (1387). 'Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity', سامانه مدیریت نشریات علمی, 6(1), pp. 22-27.
Gorgian Mohammadi, Masumeh, Bamdad, Taravat, Parsania, Masoud, Hashemi, Hamid Reza, Puyanfard, Somayeh. Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity. سامانه مدیریت نشریات علمی, 1387; 6(1): 22-27.

Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity

Iranian Journal of Immunology
مقاله 3، دوره 6، شماره 1، خرداد 2009، صفحه 22-27    اصل مقاله (204.77 K)
نوع مقاله: Original Article
نویسندگان
Masumeh Gorgian Mohammadi1؛ Taravat Bamdad* 1؛ Masoud Parsania2؛ Hamid Reza Hashemi1؛ Somayeh Puyanfard1
1Department of Virology, School of Medical Sciences, Tarbiat Modares University
2Tehran Medical Unit, Islamic Azad University, Tehran, Iran
چکیده
Background: Herpes simplex virus type 1 is one of the most common viruses among human population. Studies demonstrate the essential role of cell mediated immunity, especially CD8+ T cells, in prevention and clearance of HSV1.
Objective: It is of great importance to improve our knowledge about the kinetics of CTL responses to primary and secondary HSV-1 infection.
Methods: Using a sensitive technique for detection and analysis of CD8+ T cells, granzyme B ELISA, the CTL activity in the spleens of Balb/c mice at various time points after intraperitoneal administration of HSV1 (strain KOS) in primary and secondary infections were determined.
Results: During acute HSV-1 infection, virus specific cytotoxic T cells were detected at day 5 post virus inoculation and peaked at day 7. Six hours after secondary infection the activity of memory CD8+ T cells was detected and peaked at 12 hours post infection.
Conclusion: The peak of CTL activity was found to be day 7 post infection in primary HSV-1 infections which decreased with time. In secondary infections, the activity of CTLs reached the highest level at 12 hours post infection.
کلیدواژه‌ها
HSV-1؛ CTL؛ Granzyme B
آمار
تعداد مشاهده مقاله: 1,082
تعداد دریافت فایل اصل مقاله: 590


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب