پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شمارهها | 1,149 |
| تعداد مقالات | 10,519 |
| تعداد مشاهده مقاله | 45,427,402 |
| تعداد دریافت فایل اصل مقاله | 11,296,916 |
Human Leukocyte Antigen B27 in 453 Asian Indian Patients with Seronegative Spondyloarthropathy | ||
| Iranian Journal of Immunology | ||
| مقاله 8، دوره 7، شماره 4، اسفند 2010، صفحه 252-256 اصل مقاله (43.2 K) | ||
| نوع مقاله: Short Paper | ||
| نویسندگان | ||
| Mahendra Narain Mishra* 1؛ Vinay Singai2 | ||
| 1Department of Pathology, Command Hospital (SC) | ||
| 2Department of Internal Medicine and Rheumatology, Command Hospital (SC), Pune, INDIA | ||
| چکیده | ||
| Background: Spondyloarthropathies are a group of closely related inflammatory arthritis which involve the axial skeleton and are negative for rheumatoid factor. Objective: This case-control study was conducted to examine HLA- B27 positivity in patients with seronegative spondyloarthritis (SSA) as per ESSG criteria and compare the frequency with healthy controls because a lower positivity is reported in Indians. Method: The study included 453 patients and 200 controls. HLA -B27 typing was done by microlymphocytoxicity and/or by sequence specific primers (SSP) using commercial kits. Patients were categorised as Ankylosing Spondylitis (AS), Undifferentiated Spondyloarthropathy, SSA with inflammatory bowel disease, reactive arthritis, psoriatic arthritis and juvenile spondyloarthropathy. Results: HLA-B27 antigen was present in 56% of patient and 3.5% controls with highest frequency in juvenile spondyloarthropathy (80%), followed by AS (76%). The P value < 0.001 for all categories of SSA and overall Odds ratio was 34.9. Conclusion: This study showed HLA-B27 frequency slightly lower than reported in Caucasian SSA patients and in our opinion HLA- B27 testing is extremely useful in young patients with suspected SSA. | ||
| کلیدواژهها | ||
| HLA- B27؛ Spondylarthropathies؛ Asian Continental Ancestry Group | ||
|
آمار تعداد مشاهده مقاله: 1,063 تعداد دریافت فایل اصل مقاله: 880 |
||