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AMirshahrokhi, Keyvan, Ghazi-khansari, Mahmoud, Mohammadi-Farani, Ahmad, Karimian, Golnar. (1389). Effect of captopril on TNF-α and IL-10 in the livers of Bile Duct ligated Rats. سامانه مدیریت نشریات علمی, 7(4), 247-251.
Keyvan AMirshahrokhi; Mahmoud Ghazi-khansari; Ahmad Mohammadi-Farani; Golnar Karimian. "Effect of captopril on TNF-α and IL-10 in the livers of Bile Duct ligated Rats". سامانه مدیریت نشریات علمی, 7, 4, 1389, 247-251.
AMirshahrokhi, Keyvan, Ghazi-khansari, Mahmoud, Mohammadi-Farani, Ahmad, Karimian, Golnar. (1389). 'Effect of captopril on TNF-α and IL-10 in the livers of Bile Duct ligated Rats', سامانه مدیریت نشریات علمی, 7(4), pp. 247-251.
AMirshahrokhi, Keyvan, Ghazi-khansari, Mahmoud, Mohammadi-Farani, Ahmad, Karimian, Golnar. Effect of captopril on TNF-α and IL-10 in the livers of Bile Duct ligated Rats. سامانه مدیریت نشریات علمی, 1389; 7(4): 247-251.

Effect of captopril on TNF-α and IL-10 in the livers of Bile Duct ligated Rats

Iranian Journal of Immunology
مقاله 7، دوره 7، شماره 4، اسفند 2010، صفحه 247-251    اصل مقاله (370.07 K)
نوع مقاله: Short Paper
نویسندگان
Keyvan AMirshahrokhi* 1، 2؛ Mahmoud Ghazi-khansari1؛ Ahmad Mohammadi-Farani1، 3؛ Golnar Karimian1
1Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of Pharmacology, School of Medicine, Ardebil University of Medical Sciences, Ardebil, Iran
3Department of Pharmacology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Background: The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensinconverting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats.
Objective: The present study was conducted to investigate the effects of captopril on cytokine production in hepatic fibrosis induced by a bile duct ligation model in rats.
Methods: Male rats were divided into four groups including; control, sham operated, BDL, and BDL plus captopril (10 mg/kg/day, orally). After 28 days of treatment, the livers were removed for cytokine analysis. Hepatic interleukin (IL)-10 and tumor necrosis factor (TNF)-α levels were measured.
Results: Captopril treatment decreased the hepatic content of the proinflammatory cytokine TNF-α and increased the anti-inflammatory cytokine IL-10.
Conclusion: the present study suggests that the protective effect of captopril on hepatic fibrosis is likely to be mediated by cytokine production.
کلیدواژه‌ها
Captopril؛ Hepatic fibrosis؛ IL-10؛ TNF-α
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