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Asadikaram, Gholamreza, Asiabanha, Majid, Sayadi, Ahmadreza, Jafarzadeh, Abdollah, Hassanshahi, Gholamhossein. (1389). Impact of Opium on the Serum Levels of TGF-β in Diabetic, Addicted and Addicted-Diabetic Rats. سامانه مدیریت نشریات علمی, 7(3), 186-192.
Gholamreza Asadikaram; Majid Asiabanha; Ahmadreza Sayadi; Abdollah Jafarzadeh; Gholamhossein Hassanshahi. "Impact of Opium on the Serum Levels of TGF-β in Diabetic, Addicted and Addicted-Diabetic Rats". سامانه مدیریت نشریات علمی, 7, 3, 1389, 186-192.
Asadikaram, Gholamreza, Asiabanha, Majid, Sayadi, Ahmadreza, Jafarzadeh, Abdollah, Hassanshahi, Gholamhossein. (1389). 'Impact of Opium on the Serum Levels of TGF-β in Diabetic, Addicted and Addicted-Diabetic Rats', سامانه مدیریت نشریات علمی, 7(3), pp. 186-192.
Asadikaram, Gholamreza, Asiabanha, Majid, Sayadi, Ahmadreza, Jafarzadeh, Abdollah, Hassanshahi, Gholamhossein. Impact of Opium on the Serum Levels of TGF-β in Diabetic, Addicted and Addicted-Diabetic Rats. سامانه مدیریت نشریات علمی, 1389; 7(3): 186-192.

Impact of Opium on the Serum Levels of TGF-β in Diabetic, Addicted and Addicted-Diabetic Rats

Iranian Journal of Immunology
مقاله 6، دوره 7، شماره 3، آذر 2010، صفحه 186-192    اصل مقاله (1.38 M)
نوع مقاله: Original Article
نویسندگان
Gholamreza Asadikaram* 1، 2؛ Majid Asiabanha3؛ Ahmadreza Sayadi4؛ Abdollah Jafarzadeh5؛ Gholamhossein Hassanshahi6
1Department of Clinical Biochemistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2Department of Clinical Biochemistry, Kerman University of Medical Sciences, Kerman, Iran
3Department of Clinical Biochemistry, Qazvin University of Medical Sciences, Qazvin, Iran
4Departments of Psychology
5Immunology
6Hematology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
چکیده
Background: Several cells of immune system such as regulatory T cells and macrophages secrete transforming growth factor-β (TGF-β) in response to different stimuli. This cytokine has inhibitory effect on immune system and diminished production of this cytokine is associated with autoimmune disorders.
Objective: The aim of this study was to evaluate the influence of opium addiction on serum level of TGF-β in male and female diabetic and non-diabetic Wistar rats.
Methods: This experimental study was performed on normal, opium addicted, diabetic and addicted-diabetic male and female rats. Serum level of TGF-β was measured by ELISA.
Results: The results of our study indicated that the mean serum level of TGF-β in female addicted rats was significantly increased compared to control group (p<0.004). Conversely, in male addicted rats the mean serum level of TGF-β was lower compared with control (p<0.065).
Conclusion: Our results suggest that opium and its derivatives have differential inductive effects on the cytokine expression in male and female rats.
کلیدواژه‌ها
addiction؛ Diabetes؛ opium؛ TGF-β
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