LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,093
تعداد مقالات10,023
تعداد مشاهده مقاله27,255,159
تعداد دریافت فایل اصل مقاله7,488,397
Ebrahimi, Hasan, Soleimani, Masoud, Kazemi Arabadadi, Mohammad, Ajmadbeigi, Naser, Hassanshahi, Gholamhossein, Farjadfar, Akbar, Kennedy, Derek. (1388). An In Vitro Assay to Evaluate the Immunomodulatory Effects of Unrestricted Somatic Stem Cells. سامانه مدیریت نشریات علمی, 7(1), 30-38.
Hasan Ebrahimi; Masoud Soleimani; Mohammad Kazemi Arabadadi; Naser Ajmadbeigi; Gholamhossein Hassanshahi; Akbar Farjadfar; Derek Kennedy. "An In Vitro Assay to Evaluate the Immunomodulatory Effects of Unrestricted Somatic Stem Cells". سامانه مدیریت نشریات علمی, 7, 1, 1388, 30-38.
Ebrahimi, Hasan, Soleimani, Masoud, Kazemi Arabadadi, Mohammad, Ajmadbeigi, Naser, Hassanshahi, Gholamhossein, Farjadfar, Akbar, Kennedy, Derek. (1388). 'An In Vitro Assay to Evaluate the Immunomodulatory Effects of Unrestricted Somatic Stem Cells', سامانه مدیریت نشریات علمی, 7(1), pp. 30-38.
Ebrahimi, Hasan, Soleimani, Masoud, Kazemi Arabadadi, Mohammad, Ajmadbeigi, Naser, Hassanshahi, Gholamhossein, Farjadfar, Akbar, Kennedy, Derek. An In Vitro Assay to Evaluate the Immunomodulatory Effects of Unrestricted Somatic Stem Cells. سامانه مدیریت نشریات علمی, 1388; 7(1): 30-38.

An In Vitro Assay to Evaluate the Immunomodulatory Effects of Unrestricted Somatic Stem Cells

Iranian Journal of Immunology
مقاله 4، دوره 7، شماره 1، خرداد 2010، صفحه 30-38    اصل مقاله (228.16 K)
نوع مقاله: Original Article
نویسندگان
Hasan Ebrahimi1، 2؛ Masoud Soleimani* 3؛ Mohammad Kazemi Arabadadi4؛ Naser Ajmadbeigi2، 3؛ Gholamhossein Hassanshahi4؛ Akbar Farjadfar1؛ Derek Kennedy5
1Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran
2Stem Cell Department, Stem Cell Research Center, Tehran, Iran
3Department of Hematology, Tarbiat Modares University, Tehran, Iran
4Department of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
5School of Biomolecular and Biomedical Sciences, Eskitis Institute for Cell and Molecular Therapies, Griffith University Nathan, Queensland, Australia
چکیده
Background: Unrestricted somatic stem cells (USSC) are cord blood stem cells that have been considered as candidates for the regulation of immune responses. Therefore, potential exists for their use in the suppression of immune response after transplantation surgery.
Objective: The aim of this study was evaluation of the effect of USSC on mixed lymphocyte reaction (MLR) as a model for graft rejection.
Methods: USSC and mesanchymal stem cells (MSC) were isolated and cultured from cord blood and bone morrow, respectively. The immunophenotypes of USSC and MSC were evaluated by flow cytometery and USSC and MSC were co-cultured with peripheral blood lympho-cytes (PBL) in an MLR to evaluate the immunomodulatory effect of these cells as a percentage of the control response.
Results: Current study demonstrated that prolifera-tion of lymphocytes in the MLR was decreased after treatment with USSC, in a similar fashion to that seen with MSC.
Conclusion: It can be concluded that USSC have simi-lar regulatory effects as MSC on the MLR, which can be used as an indicator for poten-tial organ rejection after transplantation. Therefore, the immunregulatory effect of these cells could be used in the clinic during organ transplantation and in the management of autoimmunity.
کلیدواژه‌ها
Mesanchymal Stem Cells؛ Mixed Lymphocyte Reaction؛ Transplantation
آمار
تعداد مشاهده مقاله: 1,114
تعداد دریافت فایل اصل مقاله: 760


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب